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Bone Marrow Transplantation

  • Jorge Sierra
  • Tomas Franquet
Chapter
  • 821 Downloads
Part of the Medical Radiology book series (MEDRAD)

Abstract

Hematopoietic transplantation is increasingly being used as treatment for a variety of severe diseases. Data from International Registries indicate that more than 25,000 transplants are performed every year in Europe, and a similar number in the United States (US) (Copelan 2006; Gratwohl et al. 2007). The objectives of this procedure are: (1) to replace hematopoiesis affected by a severe and irreversible disorder, (2) to rescue the patient from intense marrow toxicity induced by high-dose chemotherapy and/or radiation, and (3) to use a fraction of cells contained in the graft as anti-tumor immunotherapy. Of note, one or more of these objectives may be pursued in a particular situation; for example, in a patient with acute leukemia, transplantation aims to replace the neoplastic hematopoiesis by administering high-dose cytotoxic therapy and taking advantage of the graft-versus-leukemia effect of donor T-lymphocytes from the graft. In contrast, in aplastic anemia the only goal of the procedure is to restore an adequate hematopoiesis.

Keywords

Bone Marrow Transplantation Invasive Aspergillosis Chronic GVHD Bronchiolitis Obliterans Diffuse Alveolar Hemorrhage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Jorge Sierra
    • 1
  • Tomas Franquet
    • 2
  1. 1.Clinical Hematology and Hematopoietic Transplantation Program Hospital de la Santa Creu i Sant PauUniversität Autönoma de BarcelonaBarcelonaSpain
  2. 2.Department of RadiologyHospital de Saint PauBarcelonaSpain

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