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The Role of Neuropeptide Endopeptidases in Cutaneous Immunity

  • T. E. Scholzen
Chapter
  • 928 Downloads
  • Proteolytic processing and degradation plays an important role in modulating the generation and bioactivity of neuroendocrine peptide mediators, a class of key molecules in cutaneous biology.

  • Accordingly, the cellular localization and expression, and the molecular biology and structural properties of selected intracellular prohormone convertases and ectopically expressed zinc-binding metalloendoproteases are discussed.

  • A special reference will be made to the physiologic and pathophysiologic significance of these endopeptidases in cutaneous immunobiology.

  • Because of the number of pathologically relevant changes in inflammation and tumor progression that can be directly attributed to neprilysin and angiotensin-converting enzyme, a particular focus will be on the role of these enzymes in modulating innate and adaptive immune responses in the skin.

Keywords

Angiotensin Converting Enzyme Alopecia Areata Dipeptidyl Peptidase Neutral Endopeptidase Transporter Associate With Antigen Presentation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ACE

Angiotensin-converting enzyme

ACTH

Adrenocorticotropin

Ag

Antigen

Ang

Angiotensin

BK

Bradykinin

CGRP

Calcitonin gene-related peptide

CTCL

Cutaneous T-cell lymphomas

DC

Dendritic cell(s)

DPIV

Dipeptidyl peptidase IV

EAE

Experimental autoimmune encephalomyelitis

ECE

Endothelin-converting enzyme

EC

Endothelial cells

END

Endorphin

MCx

Melanocortin receptor

MHC

Major histocompatibility complex

MSH

Melanocytestimulating hormone

NEP

Neprilysin

PACAP

Pituitary adenylate-cyclase-activating polypeptide

PC

Prohormone convertase

POMC

Proopiomelanocortin

SP

Substance P

TC

T-cell(s)

TH

helper T-cells

Teff

Effector T-cells

VIP

Vasoactive intestinal peptide

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • T. E. Scholzen
    • 1
  1. 1.Ludwig-Boltzmann Institute of Cell Biology and Immunobiology of the Skin Department of DermatologyUniversity of MünsterMünsterGermany

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