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Shock Waves pp 719-724 | Cite as

Evolution of the design of Venturi devices for the delivery of dry particles to skin or mucosal tissue

  • G. Costigan
  • Y. Liu
  • G. L. Brown
  • F. V. Carter
  • B. J. Bellhouse
Conference paper

Abstract

The behaviour of bursting membrane devices, used to accelerate powder particles to velocities high enough to penetrate the skin, has been extensively studied at Oxford University. Over-expansion of a supersonic jet leads to flow separation, and powder concentrates in this separated jet [1,2]. Correctly expanded shock tube devices, which produce uniform gas velocities[4], require the powder to be delivered over a narrow time window (of order 0.2 ms) to be accelerated to maximum velocity. This paper reviews the evolution of devices designed to use the Venturi effect to entrain particles into a quasi-steady gas flow.

Keywords

Mach Number Particle Image Velocimetry Parallel Section Computational Fluid Dynamic Result Swirl Ratio 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    B.J. Bellhouse, N.J. Quinlan, R.W. Ainsworth: ‘Needle-less Delivery of Drugs in Dry Powder Form Using Shock Waves and Supersonic Gas Flow’. In: Proc. 21st Int. Symp. on Shock Waves, Queensland, Australia 1997 Google Scholar
  2. 2.
    M.A.F. Kendall, N.J. Quinlan, et al.: ‘The Gas-particle Dynamics of a High-speed Needle-free rug Delivery System’. In: Proc. 22nd Int. Symp. on Shock Waves, London, UK 1999 Google Scholar
  3. 3.
    G.L. Brown, J.M. Lopez: J Fluid Mech. 221, 553 (1990)ADSMathSciNetCrossRefGoogle Scholar
  4. 4.
    M.A.F. Kendall, G.L. Brown, B.J. Bellhouse: ‘Needle-free Dermal Delivery of Dry Powdered Drugs Using Contoured Shock Tubes’. In: 30th AIAA Fluid Dynamics Conference and Exhibit, Denver, USA 2000 Google Scholar

Copyright information

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • G. Costigan
    • 1
  • Y. Liu
    • 1
  • G. L. Brown
    • 1
  • F. V. Carter
    • 1
  • B. J. Bellhouse
    • 1
  1. 1.Department of Engineering ScienceUniversity of OxfordOxfordUK

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