CD30-Positive Lymphoproliferative Disorders

  • Liana NikolaenkoEmail author
  • Jasmine Zain
  • Steven T. Rosen
  • Christiane Querfeld
Part of the Cancer Treatment and Research book series (CTAR, volume 176)


Primary cutaneous CD30-positive lymphoproliferative disorders (CD30+ LPD) encompass lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (pcALCL), and borderline lesions [1]. CD30+ LPD are the second most common cutaneous T-cell lymphomas (CTCL) after mycosis fungoides (MF) and represent approximately 25% of all CTCL cases [2]. Their common phenotypic hallmark is an expression of the CD30 antigen, a cytokine receptor belonging to the tumor necrosis factor (TNF) receptor superfamily. Both LyP and pcALCL show numerous clinical, histological and immunophenotypic variants, and generally have an indolent course with a favorable prognosis. Overlapping features of LyP and pcALCL with other CD30+ T-cell lymphomas, inflammatory, and/or infectious conditions emphasize the importance of careful clinicopathologic correlation and staging.


CD30+ lymphoproliferative disorder Lymphomatoid papulosis Primary cutaneous anaplastic large cell lymphoma Borderline lesions Cutaneous T-cell lymphoma Extensive limb disease Therapeutic targets 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Liana Nikolaenko
    • 1
    Email author
  • Jasmine Zain
    • 1
    • 4
  • Steven T. Rosen
    • 1
    • 4
  • Christiane Querfeld
    • 2
    • 3
    • 4
  1. 1.Department of Hematology and Hematopoietic Cell TransplantationCity of Hope National Medical CenterDuarteUSA
  2. 2.Division of DermatologyCity of Hope National Medical CenterDuarteUSA
  3. 3.Department of PathologyCity of Hope National Medical CenterDuarteUSA
  4. 4.Toni Stephenson Lymphoma CenterCity of Hope National Medical CenterDuarteUSA

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