Advertisement

Biomedical Applications and Characteristics of Graphene Nanoparticles and Graphene-Based Nanocomposites

  • S. Rajeshkumar
  • P. Veena
Chapter
Part of the Nanotechnology in the Life Sciences book series (NALIS)

Abstract

The graphene nanoparticles have a magnificent application in biomedicine due to its various exceptional characteristics. Graphene is the strongest compound than any other metals but it is highly flexible. It has many other promising properties such as good electrical conductivity, high stability at room temperature, and biocompatibility; due to its nanosize, it can penetrate into the cells easily for diagnosis. In our review, we have discussed the application of graphene nanoparticles and graphene-based nanocomposites in the various biomedical fields. Advances in the biosensor, bioimaging, anticancer, antimicrobial, drug delivery and various other applications are demonstrated. This book chapter provides information on various metals and compounds that are involved widely with the graphene-based nanocomposites and their application.

Keywords

Graphene Nanoparticles Nanocomposites Antimicrobial Anticancer Biosensors Bioimaging Drug delivery 

Notes

Conflict of Interest

The authors declared that there is no conflict of interest.

References

  1. Acar Bozkurt P (2017) Sonochemical green synthesis of Ag/graphene nanocomposite. Ultrason Sonochem 35:397–404. https://doi.org/10.1016/j.ultsonch.2016.10.018 CrossRefPubMedGoogle Scholar
  2. Al-ani LA, Alsaadi MA, Kadir FA, Hashim NM, Julkapli NM, Yehye WA (2017) Graphene gold based nanocomposites applications in cancer diseases; efficient detection and therapeutic tools. Eur J Med Chem 139:349–366. https://doi.org/10.1016/j.ejmech.2017.07.036 CrossRefPubMedGoogle Scholar
  3. Alaqad KM, Abulkibash AM, Charles O, Hamouz SA, Saleh TA (2017) Silver nanoparticles decorated graphene modified Carbon paste electrode for molecular methimazole determination. Chem Data Collection 12:168–182. https://doi.org/10.1016/j.cdc.2017.09.003 CrossRefGoogle Scholar
  4. Ali A, Lluís J, Sánchez A, Sullivan CKO, Nooredeen M (2017) DNA biosensors based on gold nanoparticles-modified graphene oxide for the detection of breast cancer biomarkers for early diagnosis. Bioelectrochemistry 118:91–99. https://doi.org/10.1016/j.bioelechem.2017.07.002 CrossRefGoogle Scholar
  5. Alswat AA, Ahmad MB, Saleh TA (2017) Preparation and characterization of zeolite\zinc oxide-copper oxide nanocomposite: antibacterial activities. Colloids Interface Sci Commun 16:19–24. https://doi.org/10.1016/j.colcom.2016.12.003 CrossRefGoogle Scholar
  6. Amrutha VS, Anantharaju KS, Prasanna DS, Rangappa D, Shetty K, Nagabhushana H, Darshan GP (2017) Enhanced sunlight driven photocatalytic performance and visualization of latent fingerprint by green mediated ZnFe2O4–RGO nanocomposite. Arab J Chem., in print. https://doi.org/10.1016/j.arabjc.2017.11.016
  7. Anand K, Singh O, Singh MP, Kaur J, Singh RC (2014) Hydrogen sensor based on graphene/ZnO nanocomposite. Sensors Actuators B Chem 195:409–415. https://doi.org/10.1016/j.snb.2014.01.029 CrossRefGoogle Scholar
  8. Apetrei IM, Apetrei C (2018) A modified nanostructured graphene-gold nanoparticle carbon screen- printed electrode for the sensitive voltammetric detection of rutin. Measurement 114:37–43. https://doi.org/10.1016/j.measurement.2017.09.020 CrossRefGoogle Scholar
  9. Atchudan R, Edison TNJI, Perumal S, Shanmugam M, Lee YR (2017) Direct solvothermal synthesis of zinc oxide nanoparticle decorated graphene oxide nanocomposite for efficient photodegradation of azo-dyes. J Photochem Photobiol A Chem 337:100–111. https://doi.org/10.1016/j.jphotochem.2017.01.021 CrossRefGoogle Scholar
  10. Bollella P, Fusco G, Tortolini C, Sanzò G, Favero G, Gorton L, Antiochia R (2017) Beyond graphene: electrochemical sensors and biosensors for biomarkers detection. Biosens Bioelectron 89:152–166. https://doi.org/10.1016/j.bios.2016.03.068 CrossRefPubMedGoogle Scholar
  11. Chettri P, Vendamani VS, Tripathi A, Singh MK, Pathak AP, Tiwari A (2017) Green synthesis of silver nanoparticle-reduced graphene oxide using Psidium guajava and its application in SERS for the detection of methylene blue. Appl Surf Sci 406:312–318. https://doi.org/10.1016/j.apsusc.2017.02.073 CrossRefGoogle Scholar
  12. Deb A, Vimala R (2018) Camptothecin loaded graphene oxide nanoparticle functionalized with polyethylene glycol and folic acid for anticancer drug delivery. J Drug Deliv Sci Technol 43:333–342. https://doi.org/10.1016/j.jddst.2017.10.025 CrossRefGoogle Scholar
  13. Deng C, Gong J, Zhang P, Zeng G, Song B, Liu H (2017) Preparation of melamine sponge decorated with silver nanoparticles-modified graphene for water disinfection. J Colloid Interface Sci 488:26–38. https://doi.org/10.1016/j.jcis.2016.10.078 CrossRefPubMedGoogle Scholar
  14. Devi M, Kumar A (2018) Structural, thermal and dielectric properties of in-situ reduced graphene oxide—polypyrrole nanotubes nanocomposites. Mater Res Bull 97:207–214. https://doi.org/10.1016/j.materresbull.2017.09.010 CrossRefGoogle Scholar
  15. Elkhenany H, Bourdo S, Hecht S, Donnell R, Gerard D, Abdelwahed R, Dhar M (2017) Graphene nanoparticles as osteoinductive and osteoconductive platform for stem cell and bone regeneration. Nanomed Nanotechnol Biol Med 13:2117–2126. https://doi.org/10.1016/j.nano.2017.05.009 CrossRefGoogle Scholar
  16. Ganguly S, Das P, Bose M, Kanti T, Mondal S (2017) Sonochemical green reduction to prepare ag nanoparticles decorated graphene sheets for catalytic performance and antibacterial application. Ultrason Sonochem 39:577–588. https://doi.org/10.1016/j.ultsonch.2017.05.005 CrossRefPubMedGoogle Scholar
  17. Guo H, Jin H, Gui R, Wang Z, Xia J, Zhang F (2017) Electrodeposition one-step preparation of silver nanoparticles/carbon dots/reduced graphene oxide ternary dendritic nanocomposites for sensitive detection of doxorubicin. Sensors Actuators B Chem 253:50–57. https://doi.org/10.1016/j.snb.2017.06.095 CrossRefGoogle Scholar
  18. Hsieh SH, Chen WJ, Yeh TH (2015) Effect of various amounts of graphene oxide on the degradation characteristics of the ZnSe/graphene nanocomposites. Appl Surf Sci 358:63–69. https://doi.org/10.1016/j.apsusc.2015.08.220 CrossRefGoogle Scholar
  19. Ji Z, Wang Y, Yu Q et al (2017) One-step thermal synthesis of nickel nanoparticles modified graphene sheets for enzymeless glucose detection. J Colloid Interface Sci 506:678–684. https://doi.org/10.1016/j.jcis.2017.07.064 CrossRefPubMedGoogle Scholar
  20. Kavinkumar T, Varunkumar K, Ravikumar V (2017) Anticancer activity of graphene oxide-reduced graphene oxide-silver nanoparticle composites. J Colloid Interface Sci 505:1125–1133. https://doi.org/10.1016/j.jcis.2017.07.002 CrossRefPubMedGoogle Scholar
  21. Khalil I, Rahmati S, Muhd Julkapli N, Yehye WA (2017) Graphene metal nanocomposites—recent progress in electrochemical biosensing applications. J Ind Eng Chem 59:1–15. https://doi.org/10.1016/j.jiec.2017.11.001 CrossRefGoogle Scholar
  22. Khatamian M, Divband B, Farahmand-Zahed F (2016) Synthesis and characterization of zinc (II)-loaded zeolite/graphene oxide nanocomposite as a new drug carrier. Mater Sci Eng C 66:251–258. https://doi.org/10.1016/j.msec.2016.04.090 CrossRefGoogle Scholar
  23. Kim TH, Lee D, Choi JW (2017) Live cell biosensing platforms using graphene-based hybrid nanomaterials. Biosens Bioelectron 94:485–499. https://doi.org/10.1016/j.bios.2017.03.032 CrossRefPubMedGoogle Scholar
  24. Li Q, Wang Q, Yang X, Wang K, Zhang H, Nie W (2017) High sensitivity surface plasmon resonance biosensor for detection of microRNA and small molecule based on graphene oxide-gold nanoparticles composites. Talanta 174:521–526. https://doi.org/10.1016/j.talanta.2017.06.048 CrossRefPubMedGoogle Scholar
  25. Lin J, Chen X, Huang P (2016) Graphene-based nanomaterials for bioimaging. Adv Drug Deliv Rev 105:242–254. https://doi.org/10.1016/j.addr.2016.05.013 CrossRefPubMedPubMedCentralGoogle Scholar
  26. Lingamdinne LP, Choi YL, Kim IS, Yang JK, Koduru JR, Chang YY (2017) Preparation and characterization of porous reduced graphene oxide based inverse spinel nickel ferrite nanocomposite for adsorption removal of radionuclides. J Hazard Mater 326:145–156. https://doi.org/10.1016/j.jhazmat.2016.12.035 CrossRefPubMedGoogle Scholar
  27. Liu M, Pan D, Pan W, Zhu Y, Hu X, Han H, Shen D (2017) Talanta in-situ synthesis of reduced graphene oxide/gold nanoparticles modified electrode for speciation analysis of copper in seawater. Talanta 174:500–506. https://doi.org/10.1016/j.talanta.2017.06.054 CrossRefPubMedGoogle Scholar
  28. Low SS, Tan MTT, Loh HS, Khiew PS, Chiu WS (2016) Facile hydrothermal growth graphene/ZnO nanocomposite for development of enhanced biosensor. Anal Chim Acta 903:131–141. https://doi.org/10.1016/j.aca.2015.11.006 CrossRefPubMedGoogle Scholar
  29. Low SS, Loh HS, Boey JS, Khiew PS, Chiu WS, Tan MTT (2017) Sensitivity enhancement of graphene/zinc oxide nanocomposite-based electrochemical impedance genosensor for single stranded RNA detection. Biosens Bioelectron 94:365–373. https://doi.org/10.1016/j.bios.2017.02.038 CrossRefPubMedGoogle Scholar
  30. Luan VH, Bae D, Hun J, Lee W (2018) Mussel-inspired dopamine-mediated graphene hybrid with silver nanoparticles for high performance electrochemical energy storage electrodes. Compos Part B 134:141–150. https://doi.org/10.1016/j.compositesb.2017.09.070 CrossRefGoogle Scholar
  31. Luo H, Ao H, Li G et al (2017) Bacterial cellulose/graphene oxide nanocomposite as a novel drug delivery system. Curr Appl Phys 17:249–254. https://doi.org/10.1016/j.cap.2016.12.001 CrossRefGoogle Scholar
  32. Mazaheri M, Aashuri H, Simchi A (2017) Three-dimensional hybrid graphene/nickel electrodes on zinc oxide nanorod arrays as non-enzymatic glucose biosensors. Sensors Actuators B Chem 251:462–471. https://doi.org/10.1016/j.snb.2017.05.062 CrossRefGoogle Scholar
  33. Naskar A, Bera S, Bhattacharya R, Roy SS, Jana S (2018) Effect of bovine serum albumin immobilized Au–ZnO–graphene nanocomposite on human ovarian cancer cell. J Alloys Compd 734:66–74. https://doi.org/10.1016/j.jallcom.2017.11.029 CrossRefGoogle Scholar
  34. Niu X, Wen Z, Li X, Zhao W, Li X, Huang Y (2018) Fabrication of graphene and gold nanoparticle modified acupuncture needle electrode and its application in rutin analysis. Sensors Actuators B Chem 255:471–477. https://doi.org/10.1016/j.snb.2017.07.085 CrossRefGoogle Scholar
  35. Okoth OK, Yan K, Feng J, Zhang J (2018) Chemical label-free photoelectrochemical aptasensing of diclofenac based on gold nanoparticles and graphene-doped CdS. Sensors Actuators B Chem 256:334–341. https://doi.org/10.1016/j.snb.2017.10.089 CrossRefGoogle Scholar
  36. Omidvar A, Jaleh B, Nasrollahzadeh M (2017) Preparation of the GO/Pd nanocomposite and its application for the degradation of organic dyes in water. J Colloid Interface Sci 496:44–50. https://doi.org/10.1016/j.jcis.2017.01.113 CrossRefPubMedGoogle Scholar
  37. Ouadil B, Cherkaoui O, Safi M, Zahouily M (2017) Surface modification of knit polyester fabric for mechanical, electrical and UV protection properties by coating with graphene oxide, graphene and graphene/silver nanocomposites. Appl Surf Sci 414:292–302. https://doi.org/10.1016/j.apsusc.2017.04.068 CrossRefGoogle Scholar
  38. Ovsianytskyi O, Nam Y, Tsymbalenko O, Lan P (2018) Sensors and Actuators B : Chemical Highly sensitive chemiresistive H2S gas sensor based on graphene decorated with Ag nanoparticles and charged impurities. Sensors Actuators B Chem 257:278–285. https://doi.org/10.1016/j.snb.2017.10.128 CrossRefGoogle Scholar
  39. Pazarçeviren AE, Tahmasebifar A, Tezcaner A, Keskin D, Evis Z (2017) Investigation of bismuth doped bioglass/graphene oxide nanocomposites for bone tissue engineering. Ceram Int 44:3791. https://doi.org/10.1016/j.ceramint.2017.11.164 CrossRefGoogle Scholar
  40. Ramadas M, Bharath G, Ponpandian N, Ballamurugan AM (2017) Investigation on biophysical properties of hydroxyapatite/graphene oxide (HAp/GO) based binary nanocomposite for biomedical applications. Mater Chem Phys 199:179–184. https://doi.org/10.1016/j.matchemphys.2017.07.001 CrossRefGoogle Scholar
  41. Salvo P, Melai B, Calisi N, Paoletti C, Bellagambi F, Kirchhain A, Di Francesco F (2018) Graphene-based devices for measuring pH. Sensors Actuators B Chem 256:976–991. https://doi.org/10.1016/j.snb.2017.10.037 CrossRefGoogle Scholar
  42. Toloman D, Popa A, Stan M, Socaci C, Biris AR, Katona G, Iacomi F (2017) Reduced graphene oxide decorated with Fe doped SnO2 nanoparticles for humidity sensor. Appl Surf Sci 402:410–417. https://doi.org/10.1016/j.apsusc.2017.01.064 CrossRefGoogle Scholar
  43. Wang L, Zhang Y, Wu A, Wei G (2017a) Designed graphene-peptide nanocomposites for biosensor applications: a review. Anal Chim Acta 985:24–40. https://doi.org/10.1016/j.aca.2017.06.054 CrossRefPubMedGoogle Scholar
  44. Wang T, Sun Z, Huang D, Yang Z, Ji Q, Hu N, Zhang Y (2017b) Studies on NH3 gas sensing by zinc oxide nanowire-reduced graphene oxide nanocomposites. Sensors Actuators B Chem 252:284–294. https://doi.org/10.1016/j.snb.2017.05.162 CrossRefGoogle Scholar
  45. Wei T, Sun J, Zhang F, Zhang J, Chen J, Li H, Zhang XM (2017) Acetylene mediated synthesis of Au/graphene nanocomposite for selective hydrogenation. Catal Commun 93:43–46. https://doi.org/10.1016/j.catcom.2017.01.029 CrossRefGoogle Scholar
  46. Yee MSL, Khiew PS, Chiu WS, Tan YF, Kok YY, Leong CO (2016) Green synthesis of graphene-silver nanocomposites and its application as a potent marine antifouling agent. Colloids Surf B Biointerf 148:392–401. https://doi.org/10.1016/j.colsurfb.2016.09.011 CrossRefGoogle Scholar
  47. Yousefi M, Dadashpour M, Hejazi M, Hasanzadeh M, Behnam B, de la Guardia M, Mokhtarzadeh A (2017) Anti-bacterial activity of graphene oxide as a new weapon nanomaterial to combat multidrug-resistance bacteria. Mater Sci Eng C 74:568–581. https://doi.org/10.1016/j.msec.2016.12.125 CrossRefGoogle Scholar
  48. Zang Z, Zeng X, Wang M, Hu W, Liu C, Tang X (2017) Tunable photoluminescence of water-soluble AgInZnS–graphene oxide (GO) nanocomposites and their application in-vivo bioimaging. Sensors Actuators B Chem 252:1179–1186. https://doi.org/10.1016/j.snb.2017.07.144 CrossRefGoogle Scholar
  49. Zhao H, Ding R, Zhao X, Li Y, Qu L, Pei H, Zhang W (2017a) Graphene-based nanomaterials for drug and/or gene delivery, bioimaging, and tissue engineering. Drug Discov Today 22:1302–1317. https://doi.org/10.1016/j.drudis.2017.04.002 CrossRefPubMedGoogle Scholar
  50. Zhao J, Wu L, Zhan C, Shao Q, Guo Z (2017b) Overview of polymer nanocomposites : computer simulation understanding of physical properties. Polymer 133:272–287. https://doi.org/10.1016/j.polymer.2017.10.035 CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • S. Rajeshkumar
    • 1
  • P. Veena
    • 2
  1. 1.Department of Pharmacology, Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennaiIndia
  2. 2.Nanotherapy Laboratory, School of Bio-Sciences and TechnologyVellore Institute of TechnologyVelloreIndia

Personalised recommendations