Neurological Aspects of Spinal Cord Tumors
- 500 Downloads
This chapter discusses neurological aspects of spinal cord tumors, including clinical symptoms and syndromes, examination techniques, and diagnostic modalities. An emphasis is placed on earlier disease diagnosis as spinal cord tumors are known for delayed diagnoses. Usual causes for this delay consist of slow progression, an incomplete physical examination or misinterpretation of exam findings, late pursuit of imaging, imaging at the incorrect level, or nonspecific symptoms—such as back pain—that is misconstrued as the more prevalent degenerative spine disease. Every physician should maintain an elevated level of suspicion of spinal cord tumors and take the appropriate steps toward diagnosis, until neoplastic disease is definitively ruled out.
KeywordsSpinal cord tumors Intramedullary tumors Intradural-extramedullary tumors Extradural-extramedullary tumors
The authors would like to thank Dr. Xin S. Xin, DO and Dr. Ha Son Nguyen, MD for their contribution to this work.
- 14.Posner JB. Neurologic complications of Cancer. 2nd ed: Oxford University Press; 2008.Google Scholar
- 16.Blumenfeld H. Neuroanatomy through clinical cases. 2nd ed. Sunderland, MA: Sinauer Associates; 2010.Google Scholar
- 18.Uchida K, Nakajima H, Takamura T, Kobayashi S, Tsuchida T, Okazawa H, et al. Neurological improvement associated with resolution of irradiation-induced myelopathy: serial magnetic resonance imaging and positron emission tomography findings. J Neuroimaging. 2009;19(3):274–6. https://doi.org/10.1111/j.1552-6569.2008.00284.x.CrossRefPubMedGoogle Scholar
- 20.Lin V. Spinal cord medicine: principles and practice. New York: Demos Medical Publishing; 2002.Google Scholar
- 25.Wang Y, Springer S, Zhang M, McMahon KW, Kinde I, Dobbyn L, et al. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord. Proc Natl Acad Sci U S A. 2015;112(31):9704–9. https://doi.org/10.1073/pnas.1511694112.CrossRefPubMedPubMedCentralGoogle Scholar
- 31.MacCollin M, Chiocca EA, Evans DG, Friedman JM, Horvitz R, Jaramillo D, et al. Diagnostic criteria for schwannomatosis. Neurology. 2005;64(11):1838–45. https://doi.org/10.1212/01.WNL.0000163982.78900.AD.CrossRefPubMedGoogle Scholar