A New Wavelet-Based Approach for Mass Spectrometry Data Classification

  • Achraf CohenEmail author
  • Chaimaa Messaoudi
  • Hassan Badir
Part of the ICSA Book Series in Statistics book series (ICSABSS)


Proteomic patterns can help the diagnosis of the underlying pathological state of an organ such as the ovary, the lung, and the breast, to name a few. An accurate classification of mass spectrometry is a crucial point to establish a reliable diagnosis and decision process regarding the type of cancer. A statistical methodology for classifying mass spectrometry data is proposed. An overview of wavelets, principal component analysis-T2 statistic, and support vector machines is given. The study is performed on low-mass SELDI spectra derived from patients with breast cancer and from normal controls. There are 156 samples where control (normal) patients contribute with 57 samples and 99 samples are cancer. A hyperparameter optimization is conducted to select a support vector machine classification model based on grid search. The performance was evaluated with a k-fold cross validation technique and Monte-Carlo simulation with 100 replications. The average accuracy is 100% with standard error equals to 0. The averages of the sensitivity and specificity are both equal to 100%, as well as the area under the curve. The excellent performance of our proposed method is mainly due to the statistical modeling and the feature extraction procedure proposed.


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Authors and Affiliations

  1. 1.Department of Mathematics and StatisticsUniversity of West FloridaPensacolaUSA
  2. 2.National School of Applied Sciences-Tangier, ENSATAbdelmalek Essaadi UniversityTangierMorocco

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