Capsaicin is a naturally occurring compound and its versatile use is well documented. It is used as a defense mechanism by plants of genus Capsicum, family Solanaceae. It is also used as a food additive, and pharmaceutical to relieve pain. Capsaicin achieves analgesia by binding to the transient receptor potential vanilloid-1 (TRPV-1) receptor located on peripheral nerve fibers. Topical capsaicin formulations have been utilized to manage musculoskeletal-related pain. A high dose capsaicin transdermal patch formulation has been approved in the US and Europe to manage pain associated with post-herpetic neuralgia and peripheral neuropathy.