Pain pp 339-341 | Cite as


  • Rohan PradhanEmail author
  • Alaa Abd-Elsayed


Capsaicin is a naturally occurring compound and its versatile use is well documented. It is used as a defense mechanism by plants of genus Capsicum, family Solanaceae. It is also used as a food additive, and pharmaceutical to relieve pain. Capsaicin achieves analgesia by binding to the transient receptor potential vanilloid-1 (TRPV-1) receptor located on peripheral nerve fibers. Topical capsaicin formulations have been utilized to manage musculoskeletal-related pain. A high dose capsaicin transdermal patch formulation has been approved in the US and Europe to manage pain associated with post-herpetic neuralgia and peripheral neuropathy.


TRPV-1 receptors Neuropeptides Nociception Defunctionalisation Neuropathic pain 


  1. 1.
    Hayman M, Kam P. Capsaicin: a review of its pharmacology and clinical applications. Curr Anaesth Crit Care. 2008;19:338–43.CrossRefGoogle Scholar
  2. 2.
    Frias B, Merighi A. Capsaicin, nociception and pain. Molecules. 2016;21:797.CrossRefGoogle Scholar
  3. 3.
    Burness C, McCormack P. Capsaicin 8% patch: a review in peripheral neuropathic pain. Drugs. 2016;76:123–34.CrossRefGoogle Scholar
  4. 4.
    Capsaicin Dosage Forms. Lexicomp Online. Accessed 12 Sept 2017.Google Scholar
  5. 5.
    Acorda Therapeutics Inc. Qutenza® (capsaicin) 8% patch: US prescribing information. 2009. Accessed 1 Oct 2017.

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.UW Health – Department of PharmacyMadisonUSA
  2. 2.Department of AnesthesiologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

Personalised recommendations