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Pain pp 339-341 | Cite as

Capsaicin

  • Rohan PradhanEmail author
  • Alaa Abd-Elsayed
Chapter

Abstract

Capsaicin is a naturally occurring compound and its versatile use is well documented. It is used as a defense mechanism by plants of genus Capsicum, family Solanaceae. It is also used as a food additive, and pharmaceutical to relieve pain. Capsaicin achieves analgesia by binding to the transient receptor potential vanilloid-1 (TRPV-1) receptor located on peripheral nerve fibers. Topical capsaicin formulations have been utilized to manage musculoskeletal-related pain. A high dose capsaicin transdermal patch formulation has been approved in the US and Europe to manage pain associated with post-herpetic neuralgia and peripheral neuropathy.

Keywords

TRPV-1 receptors Neuropeptides Nociception Defunctionalisation Neuropathic pain 

References

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.UW Health – Department of PharmacyMadisonUSA
  2. 2.Department of AnesthesiologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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