Pain pp 335-338 | Cite as

Essential Fatty Acids in Pain Management

  • Kristina YokesEmail author


Essential fatty acids may play a role in reducing pain related to inflammation. There is modest evidence of benefit in patients with rheumatoid arthritis. There is no evidence of benefit in patients with osteoarthritis. However, robust clinical data is lacking. Presented is mechanism of action, pain-related indications, contraindications, adverse effects, drug-drug interactions and dosing recommendations for essential fatty acids with regard to pain management.


Essential fatty acid Omega-3 Omega-6 Fish oil 


  1. 1.
    Miles EA, Calder PC. Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis. Br J Nutr. 2012;107(Suppl 2):S171–84.CrossRefGoogle Scholar
  2. 2.
    Galarraga B, Ho M, Youssef HM, Hill A, McMahon H, Hall C, et al. Cod liver oil (n-3 fatty acids) as a non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis. Rheumatology (Oxford). 2008;47(5):665–9.Google Scholar
  3. 3.
    Gruenwald J, Petzold E, Busch R, Petzold HP, Graubaum HJ. Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis. Adv Ther. 2009;26(9):858–71.Google Scholar
  4. 4.
    Sentfleber NK, Nielsen SM, Andersen JR, Bliddal H, Tarp S, Lauritzen L, et al. Marine oil supplements for arthritis pain: a systematic review and meta-analysis of randomized trials. Nutrition. 2017;9(1):42.Google Scholar
  5. 5.
    Fish Oil. Natural medicines comprehensive database [Internet]. Somerville: Therapeutic Research Center; 2017 [cited 25 Jul 2017]. Available from: Subscription required to view.

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.UW Health – Department of PharmacyMadisonUSA

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