Pain pp 293-296 | Cite as

Topical Medications

  • Tatiana Tverdohleb
  • Kenneth D. Candido
  • Nebojsa Nick KnezevicEmail author


We discuss the dermatopharmacokinetics and microstructural components of the skin, differences between topical and transdermal drug delivery, and topical medication effects on peripheral neuropathy. Even though the FDA approved topical analgesics 8%-capsaicin and 5%-lidocaine patches for treating postherpetic neuralgia, there are numerous other studies conducted on the efficacy of topical ketamine cream, clonidine gel, topical gabapentin, topical baclofen, and topical phenytoin for peripheral neuropathic pain, either alone or in combination with other formulations.


Topical cream Neuropathic pain Patch Capsaicin Lidocaine 


  1. 1.
    Barry BW. Breaching the skin’s barrier to drugs. Nat Biotechnol. 2004;22:165–7.CrossRefGoogle Scholar
  2. 2.
    Knezevic NN, Tverdohleb T, Nikbin F, Knezevic I, Candido KD. Management of chronic neuropathic pain with single and compounded topical analgesics. Pain Manag. 2017;7:537–8.Google Scholar
  3. 3.
    Derry S, Rice AS, Cole P, et al. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017;1:CD007393.PubMedGoogle Scholar
  4. 4.
    Navez ML, Monella C, Bösl I, et al. 5% Lidocaine medicated plaster for the treatment of postherpetic neuralgia: a review of the clinical safety and tolerability. Pain Ther. 2015;4:1–15.CrossRefGoogle Scholar
  5. 5.
    Wrzosek A, Woron J, Dobrogowski J, et al. Topical clonidine for neuropathic pain. Cochrane Database Syst Rev. 2015;8:CD010967.PubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tatiana Tverdohleb
    • 1
  • Kenneth D. Candido
    • 1
    • 2
  • Nebojsa Nick Knezevic
    • 1
    • 2
    Email author
  1. 1.Department of AnesthesiologyAdvocate Illinois Masonic Medical CenterChicagoUSA
  2. 2.Departments of Anesthesiology and SurgeryUniversity of Illinois College of MedicineChicagoUSA

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