We discuss the dermatopharmacokinetics and microstructural components of the skin, differences between topical and transdermal drug delivery, and topical medication effects on peripheral neuropathy. Even though the FDA approved topical analgesics 8%-capsaicin and 5%-lidocaine patches for treating postherpetic neuralgia, there are numerous other studies conducted on the efficacy of topical ketamine cream, clonidine gel, topical gabapentin, topical baclofen, and topical phenytoin for peripheral neuropathic pain, either alone or in combination with other formulations.
KeywordsTopical cream Neuropathic pain Patch Capsaicin Lidocaine
- 2.Knezevic NN, Tverdohleb T, Nikbin F, Knezevic I, Candido KD. Management of chronic neuropathic pain with single and compounded topical analgesics. Pain Manag. 2017;7:537–8.Google Scholar