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Pain pp 289-292 | Cite as

Benzodiazepines

  • Christopher L. Netzel
  • Alaa Abd-ElsayedEmail author
Chapter

Abstract

Benzodiazepines produce central nervous system (CNS) depression by facilitating postsynaptic γ-aminobutyric acid (GABA)-A binding and skeletal muscle relaxation through presynaptic GABA-mediated neuronal inhibition. Though used frequently in psychiatric disorders, this class of medication has limited use in pain syndromes due to lack of proven efficacy. Instead, pain providers use intravenous midazolam for sedation during interventional pain procedures and diazepam can treat spastic central nervous system disorders such as cerebral palsy and spinal cord injury.

Keywords

Benzodiazepines Skeletal muscle relaxants Flumazenil 

References

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    Howard SS. Current therapy in pain. 1st ed. Philadelphia: Saunders; 2009. p. 470–5.Google Scholar
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    Waldman HJ. Pain management. 2nd ed. Philadelphia: Saunders; 2011. p. 924–8.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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