Pain pp 261-265 | Cite as


  • Melanie SiscoEmail author


There are numerous mechanisms that can cause various pain syndromes including nociceptive pain, neuropathic pain, and psychosomatic pain. Histamine release can be associated with pain from stimulating factors such as inflammation and allergic reactions. There are a variety of antihistamines available both over the counter and prescription to assist with controlling pain.


Pain Histamine Antihistamine Diphenhydramine H2RA Pegfilgrastim Bone pain Loratadine Chemotherapy pain 


  1. 1.
    Raffa RB. Antihistamines as analgesics. J Clin Pharm Ther. 2001;26:81–5. Google Scholar
  2. 2.
    Rumore MM, Schlichting DA. Clinical efficacy of antihistaminics as analgesics. Pain. 1986;25:7–22. Google Scholar
  3. 3.
    Lexi-Comp, Inc. Accessed 17 July 2017.
  4. 4.
    Moore, DC, Pellegrino, AE. Pegfilgrastim-induced bone pain: a review on incidence, risk factors, and evidence-based management. Ann Pharmacother. 2017:1–7.Google Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.UW Health – Department of PharmacyMadisonUSA

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