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Pain pp 17-19 | Cite as

Peripheral Mechanisms

  • Thomas S. McDowellEmail author
Chapter

Abstract

Primary nociceptive neurons are specialized sensory neurons that respond to noxious mechanical, thermal, and/or chemical stimuli. Transduction of these noxious physical stimuli into action potentials occurs in the peripheral terminals of these primary nociceptors. Changes in the conductance of specific ion channels expressed by the nociceptors cause membrane depolarization, which opens the voltage-gated sodium channels that initiate action potentials. The action potentials travel from the periphery along either unmyelinated (C-fiber) or thinly myelinated (Aδ-fiber) nociceptor axons to the central nervous system to signal the painful stimulus.

Keywords

Nociceptor Noxious stimuli Transduction TRPV1 Generator potential Action potential Pain 

References

  1. 1.
    Ringkamp M, Raja SN, Campbell JN, Meyer RA. Peripheral mechanisms of cutaneous nociception. In: McMahon SB, Koltzenburg M, Tracey I, Turk DC, editors. Wall and Melzack’s textbook of pain. 6th ed. Philadelphia: Saunders; 2013. p. 1–30.Google Scholar
  2. 2.
    Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139:267–84.Google Scholar
  3. 3.
    Dubin AE, Patapoutian A. Nociceptors: the sensors of the pain pathway. J Clin Invest. 2010;120:3760–72.Google Scholar
  4. 4.
    Gold MS. Molecular biology of sensory transduction. In: McMahon SB, Koltzenburg M, Tracey I, Turk DC, editors. Wall and Melzack’s textbook of pain. 6th ed. Philadelphia: Saunders; 2013. p. 31–47.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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