Dupuytren’s contracture is a benign fibromatosis of the palmar and digital fascia of the hand. It is a genetic, progressive and irreversible disease. This genetic disease is regarded as autosomal dominant, with variable penetrance, and implicating chromosome 16q. Siblings of patients with Dupuytren’s contracture are three times more likely to have the disease. Genes that regulate collagen breakdown are inhibited and genes that promote collagen development are promoted. Excessive myofibroblast proliferation and altered collagen matrix lead to thickened and contracted palmar fascia altering hand function. Collagen turnover is a normal part of growth, bone formation, wound healing, and strength responses to mechanical forces. This imbalance in collagen turnover leads to collagen deposition. It is most common in white males peaking in the fourth to fifth decade of life, incidence rises with increasing age, and commonly bilateral. Presented are basic histology, clinical findings, diagnostics, and treatment of Dupuytren’s contracture.
KeywordsDupuytren’s contracture Dupuytren’s disease Palmar fibroma Palmar fibromatosis
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