Scleroderma or systemic sclerosis (SSc) is a rare chronic disorder characterized by diffuse fibrosis of the skin and internal organs. It is an acquired rheumatic disease of unknown cause. The disease symptoms usually appear in the third to fifth decade of life with women affected two to three times as frequently as men. Two forms of scleroderma are generally recognized: limited (80%) and diffuse (20%). Presented are basic histology, clinical findings, diagnostics, and treatment of scleroderma.
KeywordsScleroderma Systemic sclerosis Localized scleroderma Systemic scleroderma Limited cutaneous systemic sclerosis (CREST Syndrome) Diffuse cutaneous systemic scleroderma
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