Pain pp 1019-1022 | Cite as

Comprehensive Plan for Optimal Perioperative Pain Management

  • Bimal PatelEmail author
  • Ehab Farag


Acute pain management in the perioperative setting involves utilizing a multimodal regimen inclusive but not limited to regional anesthesia, non-steroidal anti-inflammatory drugs (NSAIDs), opioids, intravenous anesthetics, as well as other drugs targeting receptors involved in pain modulation. Presented are the options available in perioperative pain management.


Acute pain Regional Opioids Multimodal NSAIDs 


  1. 1.
    Rashiq S, Dick BD. Postsurgical pain syndromes: a review for the non-pain specialist. Can J Anaesth. 2014;61(2):123–30. Epub 2013 Nov 2CrossRefGoogle Scholar
  2. 2.
    Kim SY, Kim EM, Nam KH, et al. Postoperative intravenous patient-controlled analgesia in thyroid surgery: comparison of fentanyl and ondansetron regimens with and without the nonsteroidal anti-inflammatory drug ketorolac. Thyroid. 2008;18:1285–90.CrossRefGoogle Scholar
  3. 3.
    Ghanem CI, Pérez MJ, Manautou JE, Mottino AD. Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacol Res. 2016;109:119–31.CrossRefGoogle Scholar
  4. 4.
    Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do selective cyclo-oxygenase-2 inhibitors and traditional nonsteroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. Br Med J (Clin Res Ed). 2006;332(7553):1302–8.Google Scholar
  5. 5.
    Kelly DJ, Ahmad M, Brull SJ. Preemptive analgesia I: physiological pathways and pharmacological modalities. Can J Anaesth. 2001;48:1000–10.CrossRefGoogle Scholar
  6. 6.
    Jouguelet-Lacoste J, La Colla L, Schilling D, Chelly JE. The use of intravenous infusion or single dose of low-dose ketamine for postoperative analgesia: a review of the current literature. Pain Med. 2015;16:383–403.CrossRefGoogle Scholar
  7. 7.
    De Oliveira GS, Castro-Alves LJ, Khan JH, McCarthy RJ. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology. 2013;119(1):178–90.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pain ManagementAnesthesiology Institute, Cleveland Clinic FoundationClevelandUSA
  2. 2.Cleveland Clinic Lerner College of MedicineDirector of Clinical Research, General Anesthesiology, Cleveland ClinicClevelandUSA

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