Local anesthetics block nerve conduction via blockade of voltage-gated sodium channels. The physiochemical properties of the individual drugs lead to variability in individual drug potency, onset, and duration. Systemic toxicity can occur via drug overdose, intravenous dosing, or impaired drug elimination. Clinical signs of toxicity can be manifested via the central nervous system and may progress to the cardiovascular system. Treatment of local anesthetic systemic toxicity (LAST) is directed at supportive treatment and administration of lipid emulsion.
KeywordsPharmacology Local anesthetics Regional anesthesia
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