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A Network Model Reveals That the Experimentally Observed Switch of the Granule Cell Phenotype During Epilepsy Can Maintain the Pattern Separation Function of the Dentate Gyrus

  • Alexander Hanuschkin
  • Man Yi Yim
  • Jakob WolfartEmail author
Chapter
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI)

Abstract

The model is a conductance-based neural network model of the brain circuit thought to be involved in pattern separation during hippocampal memory acquisition: the dentate gyrus (DG). In this chapter we explain the concepts of pattern separation and how it was tested in our model. Our hypothesis is that experimentally constrained homeostatic adaptations of intrinsic neuronal properties can restore the pattern separation ability of the DG network, if it was lost during epileptic excitability (Stegen et al. 2009; Young et al. 2009; Yim et al. 2015).

Notes

Acknowledgments

This work was supported by grants of the Deutsche Forschungsgemeinschaft (DFG) to JW (SFB780/C2, WO1563/1-1). AH was supported by the Bernstein Award Computational Neuroscience (to Ilka Diester).

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Alexander Hanuschkin
    • 1
  • Man Yi Yim
    • 2
  • Jakob Wolfart
    • 3
    • 4
    Email author
  1. 1.Optophysiology Lab, Department of BiologyUniversity of FreiburgFreiburgGermany
  2. 2.Center for Theoretical and Computational Neuroscience and Department of NeuroscienceThe University of Texas at AustinAustinUSA
  3. 3.Medizinische Hochschule Brandenburg Theodor FontaneNeuruppinGermany
  4. 4.Oscar Langendorff Institute of PhysiologyUniversity of RostockRostockGermany

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