Factors Affecting STDP in the Dendrites of CA1 Pyramidal Cells

  • Ausra Saudargiene
  • Bruce P. GrahamEmail author
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI)


Synaptic spike-time-dependent plasticity (STDP) is a function of the membrane depolarisation at the synapse, which is determined not only by somatic spiking activity in the postsynaptic cell but also by the synaptic site in the dendrites (distance from the cell body) and other local synaptic activities, particularly at inhibitory synapses. These factors can result in spatio-temporal gradients of STDP in a single neuron. In a pair of modelling studies (Saudargiene A, Graham BP, Biosystems 130:37–50, 2015; Saudargiene A, et al., Hippocampus 25(2):208–218, 2015), we have examined these effects for inputs onto synaptic spines at different locations in the complex apical dendrites of a CA1 pyramidal cell. The first study (Saudargiene A, Graham BP, Biosystems 130:37–50, 2015) examines the temporal signal requirements for inducing long-term potentiation (LTP) or long-term depression (LTD) at a synapse on a spine located at different locations in the dendrites. It is also determined how dendritic inhibition can alter these signalling requirements. The second study (Saudargiene A, et al., Hippocampus 25(2):208–218, 2015) moves on to explore more physiological situations involving theta and gamma rhythms in the hippocampus.


Spike-time-dependent plasticity (STDP) Long-term potentiation (LTP) Long-term depression (LTD) Dendrites Spines Inhibition Theta rhythm Gamma rhythm CA1 pyramidal cell Compartmental modelling 


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Laboratory of Biophysics and Bioinformatics, Neuroscience InstituteLithuanian University of Health SciencesKaunasLithuania
  2. 2.Division of Computing Science & MathematicsUniversity of StirlingStirlingUK

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