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AIE-Type Metal Nanoclusters: Synthesis, Luminescence, Fundamentals and Applications

  • Genji Srinivasulu Yuvasri
  • Nirmal Goswami
  • Jianping XieEmail author
Chapter

Abstract

Ultra-small metal nanoclusters (NCs) have unique electronic, optical, and chemical properties which make them attractive for many practical applications. A significant amount research has focused on luminescent metal NCs, especially on the design, fabrication, and mechanistic understanding of their luminescence properties. In this chapter, we first briefly discuss the luminescence fundamentals of well-defined metal NCs, particularly how the metallic core, ligand shell, and the redox state of the metal atoms at the core/shell influence their luminescence. Following that, we describe the impact of recently discovered aggregation-induced emission (AIE) phenomenon on the design of highly luminescent metal NCs. Examples of a series of recently reported AIE-type metal NCs along with some particular application of interest have been summarized. The findings discussed in this chapter may form a basis for further understanding, engineering, and controlling the luminescence mechanism of these novel AIE-type metal NCs.

Keywords

Metal nanoclusters Gold nanoclusters Silver nanoclusters Aggregation-induced emission (AIE) Luminescence 

References

  1. 1.
    Boisselier E, Astruc D (2009) Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev 38:1759–1782Google Scholar
  2. 2.
    Daniel M-C, Astruc D (2004) Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104:293–346Google Scholar
  3. 3.
    Talapin DV, Shevchenko EV (2016) Introduction: nanoparticle chemistry. Chem Rev 116:10343–10345Google Scholar
  4. 4.
    Grassian VH (2008) When size really matters: size-dependent properties and surface chemistry of metal and metal oxide nanoparticles in gas and liquid phase environments. J Phys Chem C 112:18303–18313Google Scholar
  5. 5.
    Kelly KL, Coronado E, Zhao LL, Schatz GC (2003) The optical properties of metal nanoparticles: the influence of size, shape, and dielectric environment. J Phys Chem B 107:668–677Google Scholar
  6. 6.
    Jin R (2015) Atomically precise metal nanoclusters: stable sizes and optical properties. Nanoscale 7:1549–1565Google Scholar
  7. 7.
    Goswami N, Yao Q, Luo Z, Li J, Chen T, Xie J (2016) Luminescent metal nanoclusters with aggregation-induced emission. J Phys Chem Lett 7:962–975Google Scholar
  8. 8.
    Goswami N, Lin F, Liu Y, Leong DT, Xie J (2016) Highly luminescent thiolated gold nanoclusters impregnated in nanogel. Chem Mater 28:4009–4016Google Scholar
  9. 9.
    Jin R, Zeng C, Zhou M, Chen Y (2016) Atomically precise colloidal metal nanoclusters and nanoparticles: fundamentals and opportunities. Chem Rev 116:10346–10413Google Scholar
  10. 10.
    Stamplecoskie KG, Kamat PV (2014) Size-dependent excited state behavior of glutathione-capped gold clusters and their light-harvesting capacity. J Am Chem Soc 136:11093–11099Google Scholar
  11. 11.
    Zhu M, Aikens CM, Hendrich MP, Gupta R, Qian H, Schatz GC, Jin R (2009) Reversible switching of magnetism in thiolate-protected Au25 superatoms. J Am Chem Soc 131:2490–2492Google Scholar
  12. 12.
    Goswami N, Yao Q, Chen T, Xie J (2016) Mechanistic exploration and controlled synthesis of precise thiolate-gold nanoclusters. Coord Chem Rev 329:1–15Google Scholar
  13. 13.
    Qian H, Zhu M, Wu Z, Jin R (2012) Quantum sized gold nanoclusters with atomic precision. Acc Chem Res 45:1470–1479Google Scholar
  14. 14.
    Chakraborty I, Pradeep T (2017) Atomically precise clusters of noble metals: emerging link between atoms and nanoparticles. Chem Rev 117:8208–8271Google Scholar
  15. 15.
    Goswami N, Luo Z, Yuan X, Leong DT, Xie J (2017) Engineering gold-based radiosensitizers for cancer radiotherapy. Mater Horiz 4:817–831Google Scholar
  16. 16.
    Zhang X-D, Luo Z, Chen J, Shen X, Song S, Sun Y, Fan S, Fan F, Leong DT, Xie J (2014) Ultrasmall Au10−12(SG)10−12 nanomolecules for high tumor specificity and cancer radiotherapy. Adv Mater 26:4565–4568Google Scholar
  17. 17.
    Zhang X-D, Luo Z, Chen J, Song S, Yuan X, Shen X, Wang H, Sun Y, Gao K, Zhang L, Fan S, Leong DT, Guo M, Xie J (2015) Ultrasmall glutathione-protected gold nanoclusters as next generation radiotherapy sensitizers with high tumor uptake and high renal clearance. Sci Rep 5:8669Google Scholar
  18. 18.
    Zhang X-D, Chen J, Luo Z, Wu D, Shen X, Song S-S, Sun Y-M, Liu P-X, Zhao J, Huo S, Fan S, Fan F, Liang X-J, Xie J (2014) Enhanced tumor accumulation of sub-2 nm gold nanoclusters for cancer radiation therapy. Adv Healthc Mater 3:133–141Google Scholar
  19. 19.
    Wu Z, Wang M, Yang J, Zheng X, Cai W, Meng G, Qian H, Wang H, Jin R (2012) Well-defined nanoclusters as fluorescent nanosensors: a case study on Au25(SG)18. Small 8:2028–2035Google Scholar
  20. 20.
    Li G, Jin R (2013) Atomically precise gold nanoclusters as new model catalysts. Acc Chem Res 46:1749–1758Google Scholar
  21. 21.
    Wang S, Meng X, Das A, Li T, Song Y, Cao T, Zhu X, Zhu M, Jin R (2014) A 200-fold quantum yield boost in the photoluminescence of silver-doped AgxAu25−x nanoclusters: the 13 th silver atom matters. Angew Chem Int Ed 53:2376–2380Google Scholar
  22. 22.
    Wu Z, Jin R (2010) On the ligand’s role in the fluorescence of gold nanoclusters. Nano Lett 10:2568–2573Google Scholar
  23. 23.
    Chen T, Yang S, Chai J, Song Y, Fan J, Rao B, Sheng H, Yu H, Zhu M (2017) Crystallization-induced emission enhancement: a novel fluorescent Au-Ag bimetallic nanocluster with precise atomic structure. Sci Adv 3:e1700956Google Scholar
  24. 24.
    Kang X, Wang S, Song Y, Jin S, Sun G, Yu H, Zhu M (2016) Bimetallic Au2Cu6 nanoclusters: strong luminescence induced by the aggregation of copper(I) complexes with gold(0) species. Angew Chem Int Ed 55:3611–3614Google Scholar
  25. 25.
    Wang J, Goswami N, Shu T, Su L, Zhang X (2018) pH-Responsive aggregation-induced emission of Au nanoclusters and crystallization of the Au(i)-thiolate shell. Mater Chem Front 2:923–928Google Scholar
  26. 26.
    Jin R, Qian H, Wu Z, Zhu Y, Zhu M, Mohanty A, Garg N (2010) Size focusing: a methodology for synthesizing atomically precise gold nanoclusters. J Phys Chem Lett 1:2903–2910Google Scholar
  27. 27.
    Fedrigo S, Harbich W, Buttet J (1993) Optical response of Ag2, Ag3, Au2, and Au3 in argon matrices. J Chem Phys 99:5712–5717Google Scholar
  28. 28.
    Zheng J, Zhou C, Yu M, Liu J (2012) Different sized luminescent gold nanoparticles. Nanoscale 4:4073–4083Google Scholar
  29. 29.
    Bigioni TP, Whetten RL, Dag Ö (2000) Near-infrared luminescence from small gold nanocrystals. J Phys Chem B 104:6983–6986Google Scholar
  30. 30.
    Zheng J, Zhang C, Dickson RM (2004) Highly fluorescent, water-soluble, size-tunable gold quantum dots. Phys Rev Lett 93:077402Google Scholar
  31. 31.
    Zheng J, Dickson RM (2002) Individual water-soluble dendrimer-encapsulated silver nanodot fluorescence. J Am Chem Soc 124:13982–13983Google Scholar
  32. 32.
    Zheng J, Nicovich PR, Dickson RM (2007) Highly fluorescent noble-metal quantum dots. Annu Rev Phys Chem 58:409–431Google Scholar
  33. 33.
    Weerawardene KLDM, Aikens CM (2018) Origin of Photoluminescence of Ag25(SR)18– nanoparticles: ligand and doping effect. J Phys Chem C 122:2440–2447Google Scholar
  34. 34.
    Chen Y, Yang T, Pan H, Yuan Y, Chen L, Liu M, Zhang K, Zhang S, Wu P, Xu J (2014) Photoemission mechanism of water-soluble silver nanoclusters: ligand-to-metal–metal charge transfer vs strong coupling between surface plasmon and emitters. J Am Chem Soc 136:1686–1689Google Scholar
  35. 35.
    Kim A, Zeng C, Zhou M, Jin R (2017) Surface engineering of Au36(SR)24 nanoclusters for photoluminescence enhancement. Part Part Syst Charact 34:1600388Google Scholar
  36. 36.
    Yu H, Rao B, Jiang W, Yang S, Zhu M (2017) The photoluminescent metal nanoclusters with atomic precision. Coord Chem Rev;https://doi.org/10.1016/j.ccr.2017.12.005Google Scholar
  37. 37.
    Deng H-H, Shi X-Q, Wang F-F, Peng H-P, Liu A-L, Xia X-H, Chen W (2017) Fabrication of water-soluble, green-emitting gold nanoclusters with a 65% photoluminescence quantum yield via host–guest recognition. Chem Mater 29:1362–1369Google Scholar
  38. 38.
    Li D, Chen Z, Mei X (2017) Fluorescence enhancement for noble metal nanoclusters. Adv Colloid Interface Sci 250:25–39Google Scholar
  39. 39.
    Wang G, Huang T, Murray RW, Menard L, Nuzzo RG (2005) Near-IR luminescence of monolayer-protected metal clusters. J Am Chem Soc 127:812–813Google Scholar
  40. 40.
    Wang G, Guo R, Kalyuzhny G, Choi J-P, Murray RW (2006) NIR luminescence intensities increase linearly with proportion of polar thiolate ligands in protecting monolayers of Au38 and Au140 quantum dots. J Phys Chem B 110:20282–20289Google Scholar
  41. 41.
    Aikens CM (2011) Electronic structure of ligand-passivated gold and silver nanoclusters. J Phys Chem Lett 2:99–104Google Scholar
  42. 42.
    Chang H-Y, Chang H-T, Hung Y-L, Hsiung T-M, Lin Y-W, Huang C-C (2013) Ligand effect on the luminescence of gold nanodots and its application for detection of total mercury ions in biological samples. RSC Adv 3:4588–4597Google Scholar
  43. 43.
    Tseng Y-T, Yuan Z, Yang Y-Y, Huang C-C, Chang H-T (2014) Photoluminescent gold nanodots: role of the accessing ligands. RSC Adv 4:33629–33635Google Scholar
  44. 44.
    Crawford SE, Andolina CM, Smith AM, Marbella LE, Johnston KA, Straney PJ, Hartmann MJ, Millstone JE (2015) Ligand-mediated “turn on,” high quantum yield near-infrared emission in small gold nanoparticles. J Am Chem Soc 137:14423–14429Google Scholar
  45. 45.
    Zhou C, Sun C, Yu M, Qin Y, Wang J, Kim M, Zheng J (2010) Luminescent gold nanoparticles with mixed valence states generated from dissociation of polymeric Au(I) thiolates. J Phys Chem C 114:7727–7732Google Scholar
  46. 46.
    Jiang J, Conroy CV, Kvetny MM, Lake GJ, Padelford JW, Ahuja T, Wang G (2014) Oxidation at the core–ligand interface of Au lipoic acid nanoclusters that enhances the near-IR luminescence. J Phys Chem C 118:20680–20687Google Scholar
  47. 47.
    Luo J, Xie Z, Lam JWY, Cheng L, Chen H, Qiu C, Kwok HS, Zhan X, Liu Y, Zhu D, Tang BZ (2001) Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole. Chem Commun 0:1740–1741Google Scholar
  48. 48.
    Hong Y, Lam JWY, Tang BZ (2011) Aggregation-induced emission. Chem Soc Rev 40:5361–5388Google Scholar
  49. 49.
    Hu R, Lager E, Aguilar-Aguilar A, Liu J, Lam JWY, Sung HHY, Williams ID, Zhong Y, Wong KS, Peña-Cabrera E, Tang BZ (2009) Twisted intramolecular charge transfer and aggregation-induced emission of BODIPY derivatives. J Phys Chem C 113:15845–15853Google Scholar
  50. 50.
    Ding D, Li K, Liu B, Tang BZ (2013) Bioprobes based on AIE fluorogens. Acc Chem Res 46:2441–2453Google Scholar
  51. 51.
    Hu R, Leung NLC, Tang BZ (2014) AIE macromolecules: syntheses, structures and functionalities. Chem Soc Rev 43:4494–4562Google Scholar
  52. 52.
    Yuan WZ, Lu P, Chen S, Lam JWY, Wang Z, Liu Y, Kwok HS, Ma Y, Tang BZ (2010) Changing the behavior of chromophores from aggregation-caused quenching to aggregation-induced emission: development of highly efficient light emitters in the solid state. Adv Mater 22:2159–2163Google Scholar
  53. 53.
    Mei J, Leung NLC, Kwok RTK, Lam JWY, Tang BZ (2015) Aggregation-induced emission: together we shine, united we soar! Chem Rev 115:11718–11940Google Scholar
  54. 54.
    Hong Y, Lam JWY, Tang BZ (2009) Aggregation-induced emission: phenomenon, mechanism and applications. Chem Commun 0:4332–4353Google Scholar
  55. 55.
    Leung CWT, Hong Y, Chen S, Zhao E, Lam JWY, Tang BZ (2013) A photostable AIE luminogen for specific mitochondrial imaging and tracking. J Am Chem Soc 135:62–65Google Scholar
  56. 56.
    Kwok RTK, Leung CWT, Lam JWY, Tang BZ (2015) Biosensing by luminogens with aggregation-induced emission characteristics. Chem Soc Rev 44:4228–4238Google Scholar
  57. 57.
    Yuan Y, Zhang C-J, Gao M, Zhang R, Tang BZ, Liu B (2015) Specific light-up bioprobe with aggregation-induced emission and activatable photoactivity for the targeted and image-guided photodynamic ablation of cancer cells. Angew Chem Int Ed 54:1780–1786Google Scholar
  58. 58.
    Xie Z, Chen C, Xu S, Li J, Zhang Y, Liu S, Xu J, Chi Z (2015) White-light emission strategy of a single organic compound with aggregation-induced emission and delayed fluorescence properties. Angew Chem Int Ed 54:7181–7184Google Scholar
  59. 59.
    Dong YQ, Lam JWY, Tang BZ (2015) Mechanochromic luminescence of aggregation-induced emission luminogens. J Phys Chem Lett 6:3429–3436Google Scholar
  60. 60.
    Xu B, He J, Mu Y, Zhu Q, Wu S, Wang Y, Zhang Y, Jin C, Lo C, Chi Z, Lien A, Liu S, Xu J (2015) Very bright mechanoluminescence and remarkable mechanochromism using a tetraphenylethene derivative with aggregation-induced emission. Chem Sci 6:3236–3241Google Scholar
  61. 61.
    Hu Q, Gao M, Feng G, Liu B (2014) Mitochondria-targeted cancer therapy using a light-up probe with aggregation-induced-emission characteristics. Angew Chem Int Ed 53:14225–14229Google Scholar
  62. 62.
    Qin W, Yang Z, Jiang Y, Lam JWY, Liang G, Kwok HS, Tang BZ (2015) Construction of efficient deep blue aggregation-induced emission luminogen from triphenylethene for nondoped organic light-emitting diodes. Chem Mater 27:3892–3901Google Scholar
  63. 63.
    Chen Z, Zhang J, Song M, Yin J, Yu G-A, Liu SH (2015) A novel fluorene-based aggregation-induced emission (AIE)-active gold(i) complex with crystallization-induced emission enhancement (CIEE) and reversible mechanochromism characteristics. Chem Commun 51:326–329Google Scholar
  64. 64.
    Zhang X, Zhang X, Tao L, Chi Z, Xu J, Wei Y (2014) Aggregation induced emission-based fluorescent nanoparticles: fabrication methodologies and biomedical applications. J Mater Chem B 2:4398–4414Google Scholar
  65. 65.
    Li K, Qin W, Ding D, Tomczak N, Geng J, Liu R, Liu J, Zhang X, Liu H, Liu B, Tang BZ (2013) Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing. Sci Rep 3:1150Google Scholar
  66. 66.
    Liang J, Kwok RTK, Shi H, Tang BZ, Liu B (2013) Fluorescent light-up probe with aggregation-induced emission characteristics for alkaline phosphatase sensing and activity study. ACS Appl Mater Interfaces 5:8784–8789Google Scholar
  67. 67.
    Li K, Zhu Z, Cai P, Liu R, Tomczak N, Ding D, Liu J, Qin W, Zhao Z, Hu Y, Chen X, Tang BZ, Liu B (2013) Organic dots with aggregation-induced emission (AIE Dots) characteristics for dual-color cell tracing. Chem Mater 25:4181–4187Google Scholar
  68. 68.
    Feng G, Tay CY, Chui QX, Liu R, Tomczak N, Liu J, Tang BZ, Leong DT, Liu B (2014) Ultrabright organic dots with aggregation-induced emission characteristics for cell tracking. Biomaterials 35:8669–8677Google Scholar
  69. 69.
    Zhang C-J, Hu Q, Feng G, Zhang R, Yuan Y, Lu X, Liu B (2015) Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics. Chem Sci 6:4580–4586Google Scholar
  70. 70.
    Xu S, Yuan Y, Cai X, Zhang C-J, Hu F, Liang J, Zhang G, Zhang D, Liu B (2015) Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics. Chem Sci 6:5824–5830Google Scholar
  71. 71.
    Yuning H (2016) Aggregation-induced emission—fluorophores and applications. Methods Appl Fluoresc 4:022003Google Scholar
  72. 72.
    Liu J, Lam JWY, Tang BZ (2009) Aggregation-induced emission of silole molecules and polymers: fundamental and applications. J Inorg Organomet Polym Mater 19:249Google Scholar
  73. 73.
    Chen J, Xie Z, Lam JWY, Law CCW, Tang BZ (2003) Silole-containing polyacetylenes. synthesis, thermal stability, light emission, nanodimensional aggregation, and restricted intramolecular rotation. Macromolecules 36:1108–1117Google Scholar
  74. 74.
    Li Z, Dong YQ, Lam JWY, Sun J, Qin A, Häußler M, Dong YP, Sung HHY, Williams ID, Kwok HS, Tang BZ (2009) Functionalized siloles: versatile synthesis, aggregation-induced emission, and sensory and device applications. Adv Funct Mater 19:905–917Google Scholar
  75. 75.
    Mei J, Hong Y, Lam JWY, Qin A, Tang Y, Tang BZ (2014) Aggregation-induced emission: the whole is more brilliant than the parts. Adv Mater 26:5429–5479Google Scholar
  76. 76.
    Luo Z, Yuan X, Yu Y, Zhang Q, Leong DT, Lee JY, Xie J (2012) From aggregation-induced emission of Au(I)–thiolate complexes to ultrabright Au(0)@Au(I)–thiolate core–shell nanoclusters. J Am Chem Soc 134:16662–16670Google Scholar
  77. 77.
    Yu Y, Luo Z, Chevrier DM, Leong DT, Zhang P, D-e J, Xie J (2014) Identification of a highly luminescent Au22(SG)18 nanocluster. J Am Chem Soc 136:1246–1249Google Scholar
  78. 78.
    Wang Z, Xiong Y, Kershaw SV, Chen B, Yang X, Goswami N, Lai W-F, Xie J, Rogach AL (2017) In situ fabrication of flexible, thermally stable, large-area, strongly luminescent copper nanocluster/polymer composite films. Chem Mater 29:10206–10211Google Scholar
  79. 79.
    Chang H-C, Chang Y-F, Fan N-C, Ho J-aA (2014) Facile preparation of high-quantum-yield gold nanoclusters: application to probing mercuric ions and biothiols. ACS Appl Mater Interfaces 6:18824–18831Google Scholar
  80. 80.
    Zhang J, Yuan Y, Liang G, Arshad MN, Albar HA, Sobahi TR, Yu S-H (2015) A microwave-facilitated rapid synthesis of gold nanoclusters with tunable optical properties for sensing ions and fluorescent ink. Chem Commun 51:10539–10542Google Scholar
  81. 81.
    Zheng K, Yuan X, Kuah K, Luo Z, Yao Q, Zhang Q, Xie J (2015) Boiling water synthesis of ultrastable thiolated silver nanoclusters with aggregation-induced emission. Chem Commun 51:15165–15168Google Scholar
  82. 82.
    Ganguly M, Pal A, Negishi Y, Pal T (2013) Synthesis of highly fluorescent silver clusters on gold(I) surface. Langmuir 29:2033–2043Google Scholar
  83. 83.
    Jia X, Yang X, Li J, Li D, Wang E (2014) Stable Cu nanoclusters: from an aggregation-induced emission mechanism to biosensing and catalytic applications. Chem Commun 50:237–239Google Scholar
  84. 84.
    Negishi Y, Nobusada K, Tsukuda T (2005) Glutathione-protected gold clusters revisited: bridging the gap between gold(I)−thiolate complexes and thiolate-protected gold nanocrystals. J Am Chem Soc 127:5261–5270Google Scholar
  85. 85.
    Yu Y, Li J, Chen T, Tan YN, Xie J (2015) Decoupling the CO-reduction protocol to generate luminescent Au22(SR)18 nanocluster. J Phys Chem C 119:10910–10918Google Scholar
  86. 86.
    Gan Z, Lin Y, Luo L, Han G, Liu W, Liu Z, Yao C, Weng L, Liao L, Chen J, Liu X, Luo Y, Wang C, Wei S, Wu Z (2016) Fluorescent gold nanoclusters with interlocked staples and a fully thiolate-bound kernel. Angew Chem Int Ed 55:11567–11571Google Scholar
  87. 87.
    Wang W-X, Wu Y, Li H-W (2017) Regulation on the aggregation-induced emission (AIE) of DNA-templated silver nanoclusters by BSA and its hydrolysates. J Colloid Interface Sci 505:577–584Google Scholar
  88. 88.
    Qu F, Dou LL, Li NB, Luo HQ (2013) Solvatofluorochromism of polyethyleneimine-encapsulated Ag nanoclusters and their concentration-dependent fluorescence. J Mater Chem C 1:4008–4013Google Scholar
  89. 89.
    Feng L, Sun Z, Liu H, Liu M, Jiang Y, Fan C, Cai Y, Zhang S, Xu J, Wang H (2017) Silver nanoclusters with enhanced fluorescence and specific ion recognition capability triggered by alcohol solvents: a highly selective fluorimetric strategy for detecting iodide ions in urine. Chem Commun 53:9466–9469Google Scholar
  90. 90.
    Bhavitha KB, Nair AK, Perumbilavil S, Joseph S, Kala MS, Saha A, Narayanan RA, Hameed N, Thomas S, Oluwafemi OS, Kalarikkal N (2017) Investigating solvent effects on aggregation behaviour, linear and nonlinear optical properties of silver nanoclusters. Opt Mater 73:695–705Google Scholar
  91. 91.
    Yang T, Dai S, Yang S, Chen L, Liu P, Dong K, Zhou J, Chen Y, Pan H, Zhang S, Chen J, Zhang K, Wu P, Xu J (2017) Interfacial clustering-triggered fluorescence–phosphorescence dual solvoluminescence of metal nanoclusters. J Phys Chem Lett 8:3980–3985Google Scholar
  92. 92.
    Sugiuchi M, Maeba J, Okubo N, Iwamura M, Nozaki K, Konishi K (2017) Aggregation-induced fluorescence-to-phosphorescence switching of molecular gold clusters. J Am Chem Soc 139:17731–17734Google Scholar
  93. 93.
    Dou X, Yuan X, Yu Y, Luo Z, Yao Q, Leong DT, Xie J (2014) Lighting up thiolated Au@Ag nanoclusters via aggregation-induced emission. Nanoscale 6:157–161Google Scholar
  94. 94.
    Pyo K, Thanthirige VD, Kwak K, Pandurangan P, Ramakrishna G, Lee D (2015) Ultrabright luminescence from gold nanoclusters: rigidifying the Au(I)–thiolate shell. J Am Chem Soc 137:8244–8250Google Scholar
  95. 95.
    Tian R, Zhang S, Li M, Zhou Y, Lu B, Yan D, Wei M, Evans DG, Duan X (2015) Localization of Au nanoclusters on layered double hydroxides nanosheets: confinement-induced emission enhancement and temperature-responsive luminescence. Adv Funct Mater 25:5006–5015Google Scholar
  96. 96.
    Li B, Wang X, Shen X, Zhu W, Xu L, Zhou X (2016) Aggregation-induced emission from gold nanoclusters for use as a luminescence-enhanced nanosensor to detect trace amounts of silver ions. J Colloid Interface Sci 467:90–96Google Scholar
  97. 97.
    Tang C, Feng H, Huang Y, Qian Z (2017) Reversible luminescent nanoswitches based on aggregation-induced emission enhancement of silver nanoclusters for luminescence turn-on assay of inorganic pyrophosphatase activity. Anal Chem 89:4994–5002Google Scholar
  98. 98.
    Pyo K, Ly NH, Yoon SY, Shen Y, Choi SY, Lee SY, Joo S-W, Lee D (2017) Highly luminescent folate-functionalized Au22 Nanoclusters for Bioimaging. Adv Healthc Mater 6:1700203Google Scholar
  99. 99.
    Wu X, Li L, Zhang L, Wang T, Wang C, Su Z (2015) Multifunctional spherical gold nanocluster aggregate@polyacrylic acid@mesoporous silica nanoparticles for combined cancer dual-modal imaging and chemo-therapy. J Mater Chem B 3:2421–2425Google Scholar
  100. 100.
    Yahia-Ammar A, Sierra D, Mérola F, Hildebrandt N, Le Guével X (2016) Self-assembled gold nanoclusters for bright fluorescence imaging and enhanced drug delivery. ACS Nano 10:2591–2599Google Scholar
  101. 101.
    Cao F, Ju E, Liu C, Li W, Zhang Y, Dong K, Liu Z, Ren J, Qu X (2017) Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release. Nanoscale 9:4128–4134Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Genji Srinivasulu Yuvasri
    • 1
  • Nirmal Goswami
    • 2
  • Jianping Xie
    • 1
    Email author
  1. 1.Department of Chemical and Biomolecular EngineeringNational University of SingaporeSingaporeSingapore
  2. 2.School of EngineeringUniversity of South AustraliaAdelaideAustralia

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