Degenerative Spondylolisthesis

  • Juan D. Patino
  • Jesús Lafuente


Spondylolisthesis is described as the anterior translation of one vertebral body over another adjacent vertebra in the absence of a defect of the pars interarticularis. Patients with this condition can remain asymptomatic with only occasional back pain; chronic low back pain with or without radicular symptoms; radicular symptoms with or without neurologic deficit; and intermittent neurogenic claudication. This condition can severely restrict function, walking ability, and quality of life. Surgical treatment is offered to those patients with symptomatic spondylolisthesis who fail nonoperative treatment measures such as physical therapy and epidural steroid injections. Surgical techniques are variated, for those patients who do have spondylolisthesis and who also have significant mechanical back pain lumbar decompression with or without fusion may be offered.


  1. 1.
    Matz P, Meagher R, Lamer T, Tontz W. NASS evidence-based clinical guidelines for multidisciplinary spine care: diagnosis and treatment of degenerative lumbar spondylolisthesis. 2nd ed; 2014. p. 121. Available:
  2. 2.
    Samuel AM, Moore HG, Cunningham ME. Treatment for degenerative lumbar spondylolisthesis: current concepts and new evidence. Curr Rev Musculoskelet Med. 2017:2–10. Available:
  3. 3.
    Ghogawala Z, Resnick DK, Glassman SD, Dziura J, Shaffrey CI, Mummaneni PV. Achieving optimal outcome for degenerative lumbar spondylolisthesis: randomized controlled trial results. Neurosurgery. 2017;64:40–4. Available:{\_}suppl{\_}1/40/4093178/Achieving-Optimal-Outcome-for-Degenerative-Lumbar.
  4. 4.
    Försth P, Ólafsson G, Carlsson T, Frost A, Borgström F, Fritzell P, et al. A randomized, controlled trial of fusion surgery for lumbar spinal stenosis. N Engl J Med. 2016;374:1413–23. Available: Scholar
  5. 5.
    Weinstein JN, Tosteson TD, Lurie JD, Tosteson ANA, Blood E, Hanscom B, et al. Surgical versus nonsurgical therapy for lumbar spinal stenosis. N Engl J Med. 2008;358:794–810. Available:,
  6. 6.
    Pearson AM, Lurie JD, Blood EA, Frymoyer JW, Braeutigam H, An H, et al. Spine patient outcomes research trial: radiographic predictors of clinical outcomes after operative or nonoperative treatment of degenerative spondylolisthesis. Spine. 2008;33:2759–66.CrossRefGoogle Scholar
  7. 7.
    Lurie JD, Tosteson TD, Tosteson A, Abdu WA, Zhao W, Morgan TS, et al. Long-term outcomes of lumbar spinal stenosis: eight-year results of the Spine Patient Outcomes Research Trial (SPORT) NIH Public Access. Spine. 2015;15:63–76.CrossRefGoogle Scholar
  8. 8.
    Martin CR, Gruszczynski AT, Braunsfurth HA, Fallatah SM, O’Neil J, Wai EK. The surgical management of degenerative lumbar spondylolisthesis: a systematic review. Spine. 2007;32:1791–8. Available: Scholar
  9. 9.
    Ghogawala Z, Dziura J, Butler WE, Dai F, Terrin N, Magge SN, et al. Laminectomy plus fusion versus laminectomy alone for lumbar spondylolisthesis. N Engl J Med. 2016;374:1424–34. Available: Scholar
  10. 10.
    Baker JF, Errico TJ, Kim Y, Razi A. Degenerative spondylolisthesis: contemporary review of the role of interbody fusion. Eur J Orthop Surg Traumatol. 2017;27:169–80. Available: Scholar
  11. 11.
    Ohtori S, Koshi T, Yamashita M, Takaso M, Yamauchi K, Inoue G, et al. Single-level instrumented posterolateral fusion versus non-instrumented anterior interbody fusion for lumbar spondylolisthesis: a prospective study with a 2-year follow-up. J Orthop Sci. 2011;16:352–8.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Juan D. Patino
    • 1
  • Jesús Lafuente
    • 2
  1. 1.Neurosurgery DepartmentHospital de la Santa Creu i Sant PauBarcelonaSpain
  2. 2.Servicio de NeurocirugíaHospital del Mar, Universidad de BarcelonaBarcelonaSpain

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