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The Clinical Research Environment

  • Philip R. O. PayneEmail author
Chapter
Part of the Health Informatics book series (HI)

Abstract

The conduct of clinical research is a data- and information-intensive endeavor, involving a variety of stakeholders spanning a spectrum from patients to providers to private sector entities to governmental policymakers. Increasingly, the modern clinical research environment relies on the use of informatics tools and methods, in order to address such diverse and challenging needs. In this chapter, we introduce the major stakeholders, activities, and use cases for informatics tools and methods that characterize the clinical research environment. This includes an overview of the ways in which informatics-based approaches influence the design of clinical studies, ensuing clinical research workflow, and the dissemination of evidence and knowledge generated during such activities. Throughout this review, we will provide a number of exemplary linkages to core biomedical informatics challenges and opportunities and the foundational theories and frameworks underlying such issues. Finally, this chapter places the preceding review in the context of a number of national-scale initiatives that seek to address such needs and requirements while advancing the frontiers of discovery science and precision medicine.

Keywords

Clinical research funding Clinical research design Clinical research workflow Clinical research data management Data sharing Discovery science Precision medicine 

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Copyright information

© Springer International Publishing 2019

Authors and Affiliations

  1. 1.Institute for Informatics (I2)Washington University in St. Louis School of MedicineSt. LouisUSA

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