Endometrial biopsies and curettings are among the most common tissue specimens received in the pathology laboratory. In several respects, these specimens present a unique challenge for the surgical pathologist. The normal endometrium undergoes a variety of morphologic changes, especially during the reproductive years, when cyclical hormonal influences and pregnancy affect uterine growth. Biopsy-induced artifacts confound this heterogeneous group of morphologic changes. Endometrial sampling techniques can vary from hysteroscopy with curettage, which is considered the “gold standard,” to a “blind” biopsy with no visualization of the tissue sampled. The final specimen contains multiple, irregularly oriented tissue fragments mixed with blood and contaminating cervical tissue and mucus.
KeywordsEndometrial biopsies Endometrial curettings Abnormal uterine bleeding Infertility Products of conception Hormonal therapy
- 6.Nickelsen C. Diagnostic and curative value of uterine curettage. Acta Obstet Gynecol Scand. 1986;65:693–7.Google Scholar
- 10.Goldstein RB, Bree RL, Benson CB, Benacerraf BR, Bloss JD, Carlos R, Fleischer AC, Goldstein SR, Hunt RB, Kurman RJ, Kurtz AB, Laing FC, Parsons AK, Smith-Bindman R, Walker J. Evaluation of the woman with postmenopausal bleeding: society of Radiologists in ultrasound-sponsored consensus conference statement. J Ultrasound Med. 2001;20:1025–36.CrossRefGoogle Scholar
- 12.Fleischer A, Abramowicz J, Goncalves L, Manning F, Monteagudo A, Timor I, Toy E, editors. Sonographic techniques for early detection of ovarian and endometrial cancers. Fleischer’s sonography in obstetrics and gynecology. 8th ed. New York: McGraw Hill Education; 2018.Google Scholar
- 24.Fritz MA, Speroff L. Clinical gynecologic endocrinology and infertility. 8th ed. Philadelphia: LWW; 2010.Google Scholar