• Tricia A. Murdock
  • Emanuela F. T. Veras
  • Robert J. Kurman
  • Michael T. Mazur


Endometrial biopsies and curettings are among the most common tissue specimens received in the pathology laboratory. In several respects, these specimens present a unique challenge for the surgical pathologist. The normal endometrium undergoes a variety of morphologic changes, especially during the reproductive years, when cyclical hormonal influences and pregnancy affect uterine growth. Biopsy-induced artifacts confound this heterogeneous group of morphologic changes. Endometrial sampling techniques can vary from hysteroscopy with curettage, which is considered the “gold standard,” to a “blind” biopsy with no visualization of the tissue sampled. The final specimen contains multiple, irregularly oriented tissue fragments mixed with blood and contaminating cervical tissue and mucus.


Endometrial biopsies Endometrial curettings Abnormal uterine bleeding Infertility Products of conception Hormonal therapy 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tricia A. Murdock
    • 1
  • Emanuela F. T. Veras
    • 1
  • Robert J. Kurman
    • 1
  • Michael T. Mazur
    • 2
  1. 1.Department of PathologyThe Johns Hopkins HospitalBaltimoreUSA
  2. 2.Department of Pathology and Laboratory MedicineState University of New York Upstate Medical UniversitySyracuseUSA

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