Idiopathic Recurrent Pericarditis

  • Massimo Imazio
  • Anna Valenti
  • Antonio Brucato
  • Alberto MartiniEmail author


Idiopathic recurrent pericarditis (IRP) is a subset of pericarditis characterized by frequent true recurrences (free interval between two flares longer than 4 weeks). The term “idiopathic” refers to a non-specific etiology and is used even if an autoinflammatory pathway is suspected. The diagnosis is based on the association of typical symptoms and signs (mainly pericardial chest pain plus pericardial rub or electrocardiographic alterations or pericardial effusion). The monitoring of inflammatory markers and the use of imaging techniques help to guide management. Standard treatment includes the combination of non-steroidal anti-inflammatory drugs (NSAIDs) plus colchicine. In cases that do not respond to this combination, therapy with interleukin-1 inhibition has been remarkably effective.


Pericarditis Recurrent pericarditis Autoimmune diseases Autoinflammatory diseases Colchicine Immunotherapy Anakinra Echocardiography Cardiac magnetic resonance 



Anti-heart antibodies


Anti-intercalated-disk antibodies


The Anakinra-Treatment of Recurrent Idiopathic Pericarditis


Anti-nuclear antibodies


Activator protein-1


Antigen-presenting cell


Acetylsalicylic acid


Carcinoembryonic antigen cell adhesion molecule 1


Cardiac magnetic resonance




C-reactive protein


Computerized tomographic


Damage-associated molecular patterns


Epstein-Barr virus




European Society of Cardiology


Erythrocyte sedimentation rate


Hepatitis C virus


Human immunodeficiency virus


Human leukocyte antigens


Herpes simplex virus




Interferon γ


Idiopathic recurrent pericarditis


Intravenous immunoglobulins


Major histocompatibility complex


MHC class I chain related protein A


Nuclear factor-kappa B


Nonsteroidal anti-inflammatory drugs


Pathogen-associated molecular patterns


Postpericardiotomy syndrome


Short-tau inverted recovery


Toll-like receptor


Tumor necrosis factor


TNF receptor-associated periodic fever syndrome


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Massimo Imazio
    • 1
  • Anna Valenti
    • 2
  • Antonio Brucato
    • 2
  • Alberto Martini
    • 3
    Email author
  1. 1.University Cardiologia AOU Citta’della Salute e Della Scienza di TorinoTorinoItaly
  2. 2.Medicina Interna Ospedale Papa Giovanni XXIIIBergamoItaly
  3. 3.IRCCS Giannina Gaslini, Università di GenovaGenoaItaly

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