Study of Endogenous Fluorescence as a Function of Tissues’ Conservation Using Spectral and Lifetime Measurements on Tumor or Epileptic Cortex Excision

  • F. Poulon
  • M. Zanello
  • A. Ibrahim
  • P. Varlet
  • B. Devaux
  • D. Abi HaidarEmail author
Part of the Springer Series in Optical Sciences book series (SSOS, volume 218)


Until today the endogenous fluorescence of tissue were neglected and often consider as a source of noise in medical imaging, however recent work and future technologies seems to reconsider it as a new imaging modality in medical devices. One of the precursor fields for the use of autofluorescence in tissue is the study of cancerology, which was recognized as a powerful tool for the future of medical devices. Although many studies have been started and done in this field, there are still numerous aspects of the signal that are not well known yet such as time dependence after extraction of fresh tissues. In this work, freshly resected human samples were exanimated in order to investigate their autofluorescence changes with time. Primary results of this examination prove that fluorescence intensity and lifetime values of healthy and tumoral samples decreased slightly with time.


Lifetime measurement Spectroscopy Autofluorescence Metastasis and cortical human samples 



This Work as a part of the MEVO project was supported by “Plan Cancer” program founded by INSERM (France), by CNRS with “Défi instrumental” grant, and the Institut National de Physique Nucléaire et de Physique des Particules (IN2P3). Thanks to the PIMPA Platform partly funded by the French program “Investissement d’Avenir” run by the “Agence Nationale pour la Recherche” (grant “Infrastructure d’avenir en Biologie Santé – ANR – 11-INBS-0006”).


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • F. Poulon
    • 1
  • M. Zanello
    • 1
    • 2
  • A. Ibrahim
    • 1
  • P. Varlet
    • 3
  • B. Devaux
    • 2
  • D. Abi Haidar
    • 1
    • 4
    Email author
  1. 1.IMNC Laboratory, UMR 8165, CNRS/IN2P3Paris-Saclay UniversityOrsayFrance
  2. 2.Department of NeurosurgerySainte Anne HospitalParisFrance
  3. 3.Department of NeuropathologySainte Anne HospitalParisFrance
  4. 4.Paris Diderot UniversityParisFrance

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