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Neuronal and Mixed Neuronal-Glial Tumors

  • César R. Lacruz
  • Javier Saénz de Santamaría
  • Ricardo H. Bardales
Chapter
Part of the Essentials in Cytopathology book series (EICP, volume 13)

Abstract

This category covers a heterogeneous group of tumors that consist, in whole or in part, of cells with different degrees of neuronal differentiation (large ganglion cells or small neurocytes). In the mixed neuronal-glial tumors, another component of glial nature (most often astrocytic) is added to this neuronal component. Most neuronal and mixed neuronal-glial tumors are slow-growing and well-circumscribed neoplasms with a favorable prognosis after total resection. This chapter reviews the cytomorphologic features and differential diagnosis of these entities, which represent the group of tumors that is most frequently overgraded during intraoperative consultation.

Keywords

Intraoperative brain assessment Cytology Squash preparation Smear preparation Neuronal tumors Mixed glioneuronal tumors Ganglion cell tumors Ganglioglioma Gangliocytoma Desmoplastic infantile ganglioglioma Dysembryoplastic neuroepithelial tumor Central neurocytoma Cerebellar liponeurocytoma Rosette-forming glioneuronal tumor Spinal paraganglioma 

Suggested Reading

  1. Bleggi-Torres LF, Netto MR, Gasparetto EL, Gonçalves E, Silva A, Moro M. Dysembryoplastic neuroepithelial tumor: cytological diagnosis by intraoperative smear preparation. Diagn Cytopathol. 2002;26:92–4.CrossRefGoogle Scholar
  2. Blümcke I, Wiestler OD. Gangliogliomas: an intriguing tumor entity associated with focal epilepsies. J Neuropathol Exp Neurol. 2002;61:575–84.CrossRefGoogle Scholar
  3. Chiang JCH, Ellison DW. Molecular pathology of paediatric central nervous system tumours. J Pathol. 2017;241:159–72.CrossRefGoogle Scholar
  4. Donson AM, Kleinschmidt-DeMasters BK, Aisner DL, Bemis LT, et al. Pediatric brainstem gangliogliomas show BRAF(V600E) mutation in a high percentage of cases. Brain Pathol. 2014;24:173–83.CrossRefGoogle Scholar
  5. Daumas-Duport C, Scheithauer BW, Chodkiewicz JP, Laws ER, Vedrenne C. Dysembryoplasic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizure. Report of thirty-nine cases. Neurosurgery. 1988;23:545–56.CrossRefGoogle Scholar
  6. Chappé C, Padovani L, Scavarda D, Forest F, et al. Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF (V600E) mutation and expression. Brain Pathol. 2013;23:574–83.CrossRefGoogle Scholar
  7. Ellezam B, Theeler BJ, Luthra R, Adesina AM, Aldape KD, Gilbert MR. Recurrent PIK3CA mutations in rosette-forming glioneuronal tumor. Acta Neuropathol. 2012;123:285–7.CrossRefGoogle Scholar
  8. Fadare O, Mariappan MR, Hileeto D, Zieske AW, Kim JH, Ocal IT. Desmoplastic infantile ganglioglioma: cytologic findings and differential diagnosis on aspiration material. Cytojournal. 2005;2:1–4.CrossRefGoogle Scholar
  9. Gessi M, Moneim YA, Hammes J, Goschzik T, et al. FGFR1 mutations in rosette-forming glioneuronal tumors of the fourth ventricle. J Neuropathol Exp Neurol. 2014;73:580–4.CrossRefGoogle Scholar
  10. Gessi M, Zur Mühlen A, Hammes J, Waha A, Denkhaus D, Pietsch T. Genome-wide DNA copy number analysis of desmoplastic infantile astrocytomas and desmoplastic infantile gangliogliomas. J Neuropathol Exp Neurol. 2013;72:807–15.CrossRefGoogle Scholar
  11. González-Cámpora R, Otal-Salaverri C, Panea-Flores P, Lerma-Puertas E, Galera-Davidson H. Fine needle aspiration cytology of paraganglionic tumors. Acta Cytol. 1988;32:386–90.PubMedGoogle Scholar
  12. Ghosal N, Furtado SV, Hegde AS. Rosette forming glioneuronal tumor pineal gland and tectum: an intraoperative diagnosis on smear preparation. Diagn Cytopathol. 2010;38:590–3.PubMedGoogle Scholar
  13. Hasegawa Y, Hayabuchi Y, Namba I, Watanabe T, et al. Cytologic features of desmoplastic ganglioglioma. A report of two cases. Acta Cytol. 2001;45:1037–42.CrossRefGoogle Scholar
  14. Hernández-Martínez SJ, De Leíja-Portilla JO, Medellín-Sánchez R. Cytologic features during intraoperative assessment of central neurocytoma: a report of three cases and review of the literature. Acta Cytol. 2013;57:400–5.CrossRefGoogle Scholar
  15. Horbinski C, Kofler J, Yeaney G, Camelo-Piragua S, et al. Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas. Brain Pathol. 2011;21:564–74.CrossRefGoogle Scholar
  16. Hsu C, Kwan G, Lau Q, Bhuta S. Rosette-forming glioneuronal tumour: imaging features, histopathological correlation and a comprehensive review of literature. Br J Neurosurg. 2012;26:668–73.CrossRefGoogle Scholar
  17. Jaiswall S, Vij M, Jaiswal AK, Behari S. Squash cytomorphology of central neurocytoma. A study of five cases. Diagn Cytopathol. 2012;40:678–83.CrossRefGoogle Scholar
  18. Kinno M, Ishizawa K, Shimada S, Masaoka H, et al. Cytology is a useful tool for the diagnosis of rosette-forming glioneuronal tumour of the fourth ventricle: a report of two cases. Cytopathology. 2010;21:194–7.CrossRefGoogle Scholar
  19. Klysik M, Gavito J, Boman D, Miranda RN, Hanbali F, De Las Casas LE. Intraoperative imprint cytology of central neurocytoma: The great oligodendroglioma mimicker. Diagn Cytopathol. 2010;38:202–7.PubMedGoogle Scholar
  20. Kobayashi TK, Bamba M, Ueda M, Nishino T, et al. Cytologic diagnosis of central neurocytoma in intraoperative squash preparations: a report of 2 cases. Acta Cytol. 2010;54:209–13.CrossRefGoogle Scholar
  21. Koelsche C, Wöhrer A, Jeibmann A, Schittenhelm J, et al. Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells. Acta Neuropathol. 2013;125:891–900.CrossRefGoogle Scholar
  22. Komori T, Arai N. Dysembryoplastic neuroepithelial tumor, a pure glial tumor? Immunohistochemical and morphometric studies. Neuropathology. 2013;33:459–68.CrossRefGoogle Scholar
  23. Komori T, Scheithauer BW, Hirose T. A rosette-forming glioneuronal tumor of the fourth ventricle: infratentorial form of dysembryoplastic neuroepithelial tumor? Am J Surg Pathol. 2002;26:582–91.CrossRefGoogle Scholar
  24. Loesel LS. Fine needle aspiration cytology of a cerebral ganglioglioma. Report of a case. Acta Cytol. 1988;32:391–4.PubMedGoogle Scholar
  25. Moran CA, Rush W, Mena H. Primary spinal paragangliomas: a clinicopathological and immunohistochemical study of 30 cases. Histopathology. 1997;31:167–73.CrossRefGoogle Scholar
  26. Ng H. Cytologic features of central neurocytomas of the brain. A report of three cases. Acta Cytol. 1999;43:252–6.CrossRefGoogle Scholar
  27. Park J, Suh Y, Han J. Dysembryoplastic neuroepithelial tumor. Features distinguishing it from oligodendroglioma on cytologic squash preparations. Acta Cytol. 2003;47:624–9.CrossRefGoogle Scholar
  28. Rivera B, Gayden T, Carrot-Zhang J, Nadal J, et al. Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors. Acta Neuropathol. 2016;131:847–3.CrossRefGoogle Scholar
  29. Schild SE, Scheithauer BW, Haddock MG, Schiff D, et al. Central neurocytomas. Cancer. 1997;79:790–5.CrossRefGoogle Scholar
  30. Sugita Y, Tokunaga O, Morimatsu M, Abe H. Cytodiagnosis of central neurocytoma in intraoperative preparations. Acta Cytol. 2004;48:194–8.CrossRefGoogle Scholar
  31. Varma K, Jain S, Mandal S. Cytomorphologic spectrum in paraganglioma. Acta Cytol. 2008;52:549–56.CrossRefGoogle Scholar
  32. Wolf HK, Wietsler OD. Surgical pathology of chronic epileptic seizure disorders. Brain Pathol. 1995;3:371–80.CrossRefGoogle Scholar
  33. Zanello M, Pages M, Tauziède-Espariat A, Saffroy R, et al. Clinical imaging, histopathological and molecular characterization of anaplastic ganglioglioma. J Neuropathol Exp Neurol. 2016;75:971–80.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • César R. Lacruz
    • 1
  • Javier Saénz de Santamaría
    • 2
  • Ricardo H. Bardales
    • 3
  1. 1.Professor of PathologyComplutense University School of MedicineMadridSpain
  2. 2.Professor of PathologyUniversity Hospital Extremadura, Medical SchoolBadajozSpain
  3. 3.Pathologist, Director Ultrasound-guided Fine Needle Aspiration ServiceOutpatient Pathology Associates / Precision PathologySacramentoUSA

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