Neuronal and Mixed Neuronal-Glial Tumors

  • César R. Lacruz
  • Javier Saénz de Santamaría
  • Ricardo H. Bardales
Part of the Essentials in Cytopathology book series (EICP, volume 13)


This category covers a heterogeneous group of tumors that consist, in whole or in part, of cells with different degrees of neuronal differentiation (large ganglion cells or small neurocytes). In the mixed neuronal-glial tumors, another component of glial nature (most often astrocytic) is added to this neuronal component. Most neuronal and mixed neuronal-glial tumors are slow-growing and well-circumscribed neoplasms with a favorable prognosis after total resection. This chapter reviews the cytomorphologic features and differential diagnosis of these entities, which represent the group of tumors that is most frequently overgraded during intraoperative consultation.


Intraoperative brain assessment Cytology Squash preparation Smear preparation Neuronal tumors Mixed glioneuronal tumors Ganglion cell tumors Ganglioglioma Gangliocytoma Desmoplastic infantile ganglioglioma Dysembryoplastic neuroepithelial tumor Central neurocytoma Cerebellar liponeurocytoma Rosette-forming glioneuronal tumor Spinal paraganglioma 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • César R. Lacruz
    • 1
  • Javier Saénz de Santamaría
    • 2
  • Ricardo H. Bardales
    • 3
  1. 1.Professor of PathologyComplutense University School of MedicineMadridSpain
  2. 2.Professor of PathologyUniversity Hospital Extremadura, Medical SchoolBadajozSpain
  3. 3.Pathologist, Director Ultrasound-guided Fine Needle Aspiration ServiceOutpatient Pathology Associates / Precision PathologySacramentoUSA

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