Infectious Disease Imaging

  • Ishita Desai
  • Kara-Lee PoolEmail author


Given the continued high disease burden of infectious diseases worldwide, with communicable diseases still accounting for most deaths in low-income economies, medical imaging can and does play an important role in the diagnosis and monitoring of infectious diseases (WHO: Number of deaths: WORLD by cause., 2015). Imaging provides some fundamental advantages in that it is non-invasive and provides results relatively rapidly. Also, given the variety of modalities, e.g., radiography, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and molecular imaging such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), imaging has the potential to provide both basic and highly sophisticated information about the disease processes.


Infectious diseases Global health Radiology Ultrasound Tuberculosis Pneumonia Chest radiograph Tropical diseases Cysticercosis Chagas disease Echinococcus Schistosomiasis 


  1. 1.
    Palmer PES, Reeder MM. The imaging of tropical diseases: with epidemiological, pathological, and clinical correlation. 2 revised ed. Berlin: Springer; 2001.Google Scholar
  2. 2.
    WHO: Number of deaths: WORLD by cause; 2015.
  3. 3.
    MRG. European diagnostic imaging system market will grow modestly to almost $2.2 billion in 2017; 2013.
  4. 4.
  5. 5.
    Frost & Sullivan. Brazilian medical imaging market growth driven by socio-economic factors and private investments; 2013.
  6. 6.
    Frost & Sullivan. CEE and Russia medical imaging market forecasted to rise at $2.34 billion in 2015; 2013.
  7. 7.
    Ken Research Private Ltd. India Medical Imaging Industry Outlook to 2017—led by surging income and low penetration; 2013.
  8. 8.
    Ken Research Private Ltd. Asia Pacific medical imaging industry outlook to 2017—driven by rising lifestyle diseases and public healthcare expenditure; 2013.
  9. 9.
    Lungren MP, Peper JPC, Ordoñez AA, Jain SK. Infectious disease imaging. In: Mollura DP, Lungren MP, editors. Radiology in global health. 1st ed. New York: Springer; 2014. p. 159–80.Google Scholar
  10. 10.
    Mansfield P, Maudsley AA. Medical imaging by NMR. Br J Radiol. 1977;50:188–94.CrossRefGoogle Scholar
  11. 11.
    Santiago Restrepo C, Gimenez CR, McCarthy K. Imaging of osteomyelitis and musculoskeletal soft tissue infections: current concepts. Rheum Dis Clin N Am. 2003;29:89–109.CrossRefGoogle Scholar
  12. 12.
    Dai J. Opportunities and challenges of MRI in the developing world. Proc Int Soc Mag Reson Med. 2006:14.Google Scholar
  13. 13.
    Török E, Moran E, Cooke F. Cerebral abscess. In: Oxford handbook of infectious diseases and microbiology. Oxford: Oxford University Press; 2010. p. 771.Google Scholar
  14. 14.
    Bourne R. Fundamentals of digital imaging in medicine. London: Springer; 2010.CrossRefGoogle Scholar
  15. 15.
    Török E, Moran E, Cooke F. Cestodes. In: Oxford handbook of infectious diseases and microbiology. Oxford: Oxford University Press; 2010. p. 604–6.Google Scholar
  16. 16.
    Koh DM, Burke S, Davies N, SPG P. Transthoracic US of the chest: clinical uses and applications. Radiographics. 2002 Jan-Feb;22(1):e1.CrossRefGoogle Scholar
  17. 17.
    Bureau NJ, Chhem RK, Cardinal E. Musculoskeletal infections: US manifestations. Radiographics. 1999;19(6):1585–92.CrossRefGoogle Scholar
  18. 18.
    Shah S, Noble VE, Umulisa I, et al. Development of an ultrasound training curriculum in a limited resource international setting: successes and challenges of ultrasound training in rural Rwanda. Int J Emerg Med. 2008;1:193–6.CrossRefGoogle Scholar
  19. 19.
    Maru DS, Schwarz R, Jason A, Basu S, et al. Turning a blind eye: the mobilization of radiology services in resource-poor regions. Glob Health. 2010 Oct 14;6:18.CrossRefGoogle Scholar
  20. 20.
    Groen RS, Leow JJ, Sadasivam V, Kushner AL. Review: indications for ultrasound use in low- and middle-income countries. Tropical Med Int Health. 2011;16:1525–35.CrossRefGoogle Scholar
  21. 21.
    Shah SP, Epino H, Bukhman G, et al. Impact of the introduction of ultrasound services in a limited resource setting: rural Rwanda 2008. BMC Int Health Hum Rights. 2009;9:4.CrossRefGoogle Scholar
  22. 22.
    Spencer JK, Adler RS. Utility of portable ultrasound in a community in Ghana. J Ultrasound Med. 2008;27:1735–43.CrossRefGoogle Scholar
  23. 23.
    Belard S, Tamarozzi F, Bustinduy AL, et al. Review article: point-of-care ultrasound assessment of tropical infectious diseases – a review of applications and perspectives. Am J Trop Med Hyg. 2016;94(1):8–21.CrossRefGoogle Scholar
  24. 24.
    Condeelis J, Weissleder R. In vivo imaging in cancer. Cold Spring Harb Perspect Biol. 2010;2:a003848.CrossRefGoogle Scholar
  25. 25.
    Hammoud DA, Hoffman JM, Pomper MG. Molecular neuroimaging: from conventional to emerging techniques. Radiology. 2007;245:21–42.CrossRefGoogle Scholar
  26. 26.
    Signore A. The developing role of cytokines for imaging inflammation and infection. Cytokine. 2000;12:1445–54.CrossRefGoogle Scholar
  27. 27.
    Baum R. Theranostics, Gallium-68, and other radionuclides: a pathway to personalized diagnosis and treatment. Berlin: Springer; 2013.CrossRefGoogle Scholar
  28. 28.
    Esmail H, Lai RP, Lesosky M, et al. Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography. Nat Med. 2016;22(10):1090–3.CrossRefGoogle Scholar
  29. 29.
    Berezin EN, de Moraes JC, Hong T, et al. Pneumonia hospitalization in Brazil from 2003 to 2007. Int J Infect Dis. 2012;16:e583–90.CrossRefGoogle Scholar
  30. 30.
    Török E, Moran E, Cooke F. Retropharyngeal abscess. In: Oxford handbook of infectious diseases and microbiology. Oxford: Oxford University Press; 2010. p. 634.Google Scholar
  31. 31.
    Török E, Moran E, Cooke F. Infective endocarditis. In: Oxford handbook of infectious diseases and microbiology. Oxford: Oxford University Press; 2010. p. 670.Google Scholar
  32. 32.
    Llewelyn H, Ang HA, Lewis KE, et al. Round opacity (or opacities) >5 mm in diameter. In: Oxford handbook of clinical diagnosis. Oxford: Oxford University Press; 2009. p. 728.CrossRefGoogle Scholar
  33. 33.
    Török E, Moran E, Cooke F. Gas gangrene. In: Oxford handbook of infectious diseases and microbiology. Oxford: Oxford University Press; 2010. p. 792.Google Scholar
  34. 34.
    Tsai YF, Ku YH. Necrotizing pneumonia: a rare complication of pneumonia requiring special consideration. Curr Opin Pulm Med. 2012;18(3):246–52.CrossRefGoogle Scholar
  35. 35.
    Allen CM, Al-Jahadi HH, Irion KL, et al. Imaging lung manifestations of HIV/AIDS. Ann Thoracic Med. 2010;5(4):201–16.CrossRefGoogle Scholar
  36. 36.
    Tasaka S. Recent advances in the diagnosis of pneumocystis jirovecii pneumonia in HIV-infected adults. Expert Opin Med Diagn. 2013;7:85–97.CrossRefGoogle Scholar
  37. 37.
    World Health Organization. Global tuberculosis report; 2016.
  38. 38.
    CDC: Core Curriculum on Tuberculosis: What the clinician should know; 2016.
  39. 39.
    WHO: Frequently Asked Questions on Xpert MTB/RIF assay; 2014.
  40. 40.
    WHO: Chest Radiography in Tuberculosis Detection. 2016.
  41. 41.
    Heller T, Wallrauch C, Goblirsch S, Brunetti E. Focused assessment with sonography for HIV-associated tuberculosis: a short protocol and pictorial review. Crit Ultrasound J. 2012;4(1):21.CrossRefGoogle Scholar
  42. 42.
    Longmore M, Wilkinson IB, Davidson EH, et al. Clinical features of TB. In: Oxford handbook of clinical medicine. Oxford: Oxford University Press; 2010. p. 399.CrossRefGoogle Scholar
  43. 43.
    Burrill J, Williams CJ, Bain G, et al. Tuberculosis: a radiologic review. Radiographics. 2007;27(5):1255–73.CrossRefGoogle Scholar
  44. 44.
    Llewelyn H, Ang HA, Lewis KE, et al. Abnormal hilar shadowing—streaky. In: Oxford handbook of clinical diagnosis. Oxford: Oxford University Press; 2009. p. 742.CrossRefGoogle Scholar
  45. 45.
    Jeong YJ, Lee KS. Pulmonary tuberculosis: up-to-date imaging and management. Am J Roentgenol. 2008;191:834–44.CrossRefGoogle Scholar
  46. 46.
    Pool KL, Heuvelings CC, Belard S, Grobusch MP, Zar HJ, Bulas D, Garra B, Andronikou S. Technical aspects of mediastinal ultrasound for pediatric pulmonary tuberculosis. Pediatr Radiol. 2017 Dec;47(13):1839–48.CrossRefGoogle Scholar
  47. 47.
    Török E, Moran E, Cooke F. Mycobacterium tuberculosis. In: Oxford handbook of infectious diseases and microbiology. Oxford: Oxford University Press; 2010. p. 407.Google Scholar
  48. 48.
    Patel MN, Beningfield S, Burch V. Abdominal and pericardial ultrasound in suspected extrapulmonary or disseminated tuberculosis. S Afr Med J. 2011 Jan;101(1):39–42.CrossRefGoogle Scholar
  49. 49.
    Lee WK, Van Tonder F, Tartaglia CJ, et al. CT appearances of abdominal tuberculosis. Clin Radiol. 2012;67:596–604.CrossRefGoogle Scholar
  50. 50.
    Kornienko VN, Pronin IN. Diagnostic neuroradiology. Berlin: Springer Verlag; 2009. p. 1288. ISBN:3540756523.Google Scholar
  51. 51.
    Kim TK, Chang KH, Kim CJ, et al. Intracranial tuberculoma: comparison of MR with pathologic findings. Am J Neuroradiol. 1995;16(9):1903–8.PubMedGoogle Scholar
  52. 52.
    Carrillo-Esper R, Moreno-Castaneda L, Hernandez-Cruz AE, et al. Renal tuberculosis. Cir Cir. 2010;78:442–7.PubMedGoogle Scholar
  53. 53.
    Mukae H, Taniguchi H, Matsumoto N, et al. Clinicoradiologic features of pleuropulmonary Paragonimus westermani on Kyusyu Island. Japan Chest. 2001;120:514–20.CrossRefGoogle Scholar
  54. 54.
    Kim TS, Han J, Shim SS, et al. Pleuropulmonary paragonimiasis: CT findings in 31 patients. Am J Radiol. 2005;185:616–21.Google Scholar
  55. 55.
    Antimicrobe: Paragonimus species (Paragonimiasis); 2002.
  56. 56.
    Im JG, Whang HY, Kim WS, et al. Pleuropulmonary paragonimiasis: radiologic findings in 71 patients. Am J Roentgenol. 1992;159:39–43.CrossRefGoogle Scholar
  57. 57.
    Burivong W, Wu X, Saenkote W, et al. Thoracic radiologic manifestations of melioidosis. Curr Probl Diagn Radiol. 2012;41:199–209.CrossRefGoogle Scholar
  58. 58.
    Dhiensiri T, Puapairoj S, Susaengrat W. Pulmonary melioidosis: clinical-radiologic correlation in 183 cases in northeastern Thailand. Radiology. 1988;166:711–5.CrossRefGoogle Scholar
  59. 59.
    WHO: Global Health Observatory (GHO) data: Schistosomiasis 2015.
  60. 60.
    Sah VK, Wang L, Min X, et al. Human schistosomiasis: a diagnostic imaging focused review of a neglected disease. Radiol Infect Dis. 2015;2:150–7.CrossRefGoogle Scholar
  61. 61.
    Olveda DU, Olveda RM, Lam AK, et al. Utility of diagnostic imaging in the diagnosis and management of schistosomiasis. Clin Microbiol. 2014;3(2):142. pii: 142.CrossRefGoogle Scholar
  62. 62.
    Nunnari G, Pinzone MR, Gruttadauria S, et al. Hepatic echinococcosis: clinical and therapeutic aspects. World J Gastroenterol. 2012;18:1448–58.CrossRefGoogle Scholar
  63. 63.
    WHO Informal Working Group. International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop. 2003;85:253–61.CrossRefGoogle Scholar
  64. 64.
    Török E, Moran E, Cooke F. Cholecystitis and cholangitis. In: Oxford handbook of infectious diseases and microbiology. Oxford: Oxford University Press; 2010. p. 696.Google Scholar
  65. 65.
    Kilani T, El Hammami S. Pulmonary hydatid and other lung parasitic infections. Curr Opin Pulm Med. 2002;8:218–23.CrossRefGoogle Scholar
  66. 66.
    WHO: Chagas disease (American trypanosomiasis).
  67. 67.
    Török E, Moran E, Cooke F. Ascariasis. In: Oxford handbook of infectious diseases and microbiology. Oxford: Oxford University Press; 2010. p. 591.Google Scholar
  68. 68.
    Acquatella H. Echocardiography in Chagas heart disease. Circulation. 2007;115:1124–31.CrossRefGoogle Scholar
  69. 69.
    Lee-Felker SA, Thomas M, Felker ER, et al. Value of cardiac MRI for evaluation of chronic Chagas disease cardiomyopathy. Clin Radiol. 2016;71(6):618.e1–7.CrossRefGoogle Scholar
  70. 70.
    Rochitte CE, Oliveira PF, Andrade JM, et al. Myocardial delayed enhancement by magnetic resonance imaging in patients with Chagas’ disease: a marker of disease severity. J Am Coll Cardiol. 2005;46(8):1553e8. 9.CrossRefGoogle Scholar
  71. 71.
    Gascon J, Albajar P, Cañas E, et al. Diagnosis, management and treatment of chronic Chagas’ heart disease in areas where Trypanosoma cruzi infection is not endemic [in Spanish]. Rev Esp Cardiol. 2007;60(3):285e93.CrossRefGoogle Scholar
  72. 72.
    WHO: Soil-transmitted helminth infections.
  73. 73.
    Lim JH. Parasitic diseases in the abdomen: imaging findings. Abdom Imaging. 2008;33:130–2.CrossRefGoogle Scholar
  74. 74.
    Reeder MM. The radiological and ultrasound evaluation of ascariasis of the gastrointestinal, biliary, and respiratory tracts. Semin Roentgenol. 1998;33:57–78.CrossRefGoogle Scholar
  75. 75.
    Choudhuri H, Thappa DM, Kumar RH, et al. Bone changes in leprosy patients with disabilities/deformities (a clinico-radiological correlation). Indian J Lepr. 1999;71:203–15.PubMedGoogle Scholar
  76. 76.
    Ochoa MT, Valderrama L, Ochoa A, et al. Lepromatous and tuberculoid leprosy: clinical presentation and cytokine responses. Int J Dermatol. 1996;35(11):786–90.CrossRefGoogle Scholar
  77. 77.
    WHO: Taeniasis/cysticercosis; 2017.
  78. 78.
    Kraft R. Cysticercosis: an emerging parasitic disease. Am Fam Physician. 2007;76:91–6.PubMedGoogle Scholar
  79. 79.
    Abdel Razek AA, Watcharakorn A, Castillo M. Parasitic diseases of the central nervous system. Neuroimaging Clin N Am. 2011;21:815–41, viii.CrossRefGoogle Scholar
  80. 80.
    Kimura-Hayama ET, Higuera JA, Corona-Cedillo R, et al. Neurocysticercosis: radiologic-pathologic correlation. Radiographics. 2010;30(6):1705–19.CrossRefGoogle Scholar
  81. 81.
  82. 82.
    Lee GT, Antelo F, Mlikotic AA. Cerebral Toxoplasmosis. Radiographics. 2009;29(4):1200–5.CrossRefGoogle Scholar
  83. 83.
    Malinger G, Werner H, Rodriguez Leonel JC, et al. Prenatal brain imaging in congenital toxoplasmosis. Prenat Diagn. 2011 Sep;31(9):881–6.PubMedGoogle Scholar
  84. 84.
    WHO: Foodborne trematode infections: Clonorchiasis.
  85. 85.
    Lim JH. Radiologic findings of clonorchiasis. Am J Roentgenol. 1990;155(5):1001–8.CrossRefGoogle Scholar
  86. 86.
    Lim JH, Kim SY, Park CM. Parasitic diseases of the biliary tract. Am J Roentgenol. 2007;188(6):1596–603.CrossRefGoogle Scholar
  87. 87.
    Antimicrobe: Entamoeba histolytica (Amebiasis).
  88. 88.
    Araujo Júnior E, Carvalho FH, Tonni G, Werner H. Prenatal imaging findings in fetal Zika virus infection. Curr Opin Obstet Gynecol. 2017;29(2):95–105.CrossRefGoogle Scholar
  89. 89.
    Oliveira-Szengnfeld, et al. Congenital brain abnormalities and zika virus: what the radiologist can expect to see prenatally and postnatally. Radiology. 2016;281:1–16.CrossRefGoogle Scholar
  90. 90.
    Brasil P, Pereira JP, Moreira ME, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375(24):2321–34.CrossRefGoogle Scholar
  91. 91.
    Stegmann BJ, Carey JC. TORCH infections: toxoplasmosis, other (syphilis, varicella-zoster, parvovirus B19), rubella, cytomegalovirus and herpes infections. Current Womens Health. 2002;2(4):253–8.Google Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of RadiologyUCLALos AngelesUSA
  2. 2.Department of RadiologyUCLASanta MonicaUSA

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