Infections, Cellulitis, and Osteomyelitis

  • Silvia Bellando-Randone
  • Gemma Lepri


Patients with systemic sclerosis (SSc) may present digital ulcers (DUs) that can lead to several complications as infection, cellulitis, and osteomyelitis affecting the quality of life. Infection is a very common complication due to several factors as microangiopathy, defective activity of the immune system, the concomitant immunosuppressive treatments, and the use of contaminated medical equipments. Infection of DU represents the main predisposing condition to bone infection and inflammation (osteomyelitis) frequently accompanied by cellulitis. Laboratory findings and clinical features are important to suspect osteomyelitis, which has then to be confirmed by instrumental investigations. A multidisciplinary team is required (infectivologist, orthopedic surgeon, radiologist, and nuclear medicine physician) for the management of osteomyelitis to avoid further complications.


Systemic sclerosis Digital ulcers Infection Osteomyelitis Cellulitis Bone Instrumental examination 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Silvia Bellando-Randone
    • 1
    • 2
  • Gemma Lepri
    • 1
    • 2
  1. 1.Department of Clinical and Experimental Medicine, University of FlorenceFlorenceItaly
  2. 2.Department of Geriatric Medicine, Division of Rheumatology AOUCFlorenceItaly

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