Fragile X Syndrome

  • Rebecca KronkEmail author
  • Robyn A. Filipink


This chapter offers a synopsis of research studies identifying various sleep patterns in children with Fragile X syndrome. New research has begun to recognize sleep problems across the life span in individuals with Fragile X-associated disorders. Epidemiologic and treatment approaches involve recognizing the interaction of biopsychosocial variables which have been conceptualized using the International Classification of Functioning, Disability and Health-Children and Youth Version. There is a need for well-designed double-blind crossover studies investigating the effectiveness of medications and behavioral interventions in treating sleep problems. The immediate and long-term impact of these treatments on family satisfaction and functioning must also be measured and documented.


Fragile X syndrome Fragile X-associated disorders FMR1 allele FMRP Sleep International Classification of Functioning Disability Health 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Nursing, Duquesne UniversityPittsburghUSA
  2. 2.Fragile X Clinic, Movement Disorders Clinic, Tourette Syndrome Clinic, Division of Child NeurologyChildren’s Hospital of PittsburghPittsburghUSA

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