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Oral Cancers

  • Ronnie Levine
  • Catherine Stillman-Lowe
Chapter
Part of the BDJ Clinician’s Guides book series (BDJCG)

Abstract

The most common type of oral cancer is squamous cell carcinoma and arises from the oral mucosa lining the mouth but most commonly as ulcers in the floor of the mouth, the lateral border of the tongue or inside the lips. They may also arise within pre-existing white, red or thickened areas of mucosa and at the earliest stage may not show obvious signs of ulceration. Malignant ulcers differ from other innocent ulcers by persisting for more than 2 weeks after any cause is removed, and they do not heal or resolve spontaneously. Any ulcer present for more than 3 weeks must be investigated without delay. Globally in men they account for 2.7% of all cancers and for 1.5% in women. In parts of India, oral cancer in men accounts for over 30% of all cancer cases with tobacco and betel nut chewing being major risk factors, whereas tobacco smoking and alcohol consumption are the major risk factors in Western developed countries. The human papilloma virus (HPV) is a major cause of cervical cancers and is linked to 90% of squamous carcinoma of the oropharynx (posterior tongue, throat and tonsils). The relatively poor prognosis of oral cancer is related to late presentation, and treatment is usually surgery and may be followed by radiotherapy and/or chemotherapy.

Keywords

Cancer Oral ulceration Tobacco Alcohol HPV 

References

  1. 1.
    Globocan. Estimated cancer incidence, mortality and prevalence worldwide in 2012. International Agency for Research on Cancer. 2012. https://gco.iarc.fr/
  2. 2.
    National Cancer Registry Programme. Three-year Report of Population Based Cancer Registries: 2012-2014, Indian Council of Medical Research. 2017. http://www.ncrpindia.org/, http://www.ncdirindia.org/
  3. 3.
  4. 4.
    Radoï L, Luce D. A review of risk factors for oral cavity cancer: the importance of a standardized case definition. Community Dent Oral Epidemiol. 2013;41(2):97–109.CrossRefGoogle Scholar
  5. 5.
  6. 6.
    World Health Organization.Tobacco and oral health. WHO:Geneva. http://www.euro.who.int/en/health-topics/disease-prevention/oral-health
  7. 7.
    Werner CW, Seymour RA. Are alcohol containing mouthwashes safe? Br Dent J. 2009;207(10):E19.  https://doi.org/10.1038/sj.bdj.2009.1014.CrossRefPubMedGoogle Scholar
  8. 8.
    D’Souza G, Dempsey A. The role of HPV in head and neck cancer and review of the HPV vaccine. Prev Med. 2011;53(Sup.1):S5–1.  https://doi.org/10.1016/j.ypmed.2011.08.001.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Stanley M. Perspective: vaccinate boys too. Nature. 2012;488:S10.CrossRefGoogle Scholar
  10. 10.
    Petersen PE. Oral cancer prevention and control - the approach of the World Health Organization. Oral Oncol. 2009;45(4–5):454–60.  https://doi.org/10.1016/j.oraloncology.2008.05.023.CrossRefPubMedGoogle Scholar
  11. 11.
    The Royal College of Surgeons of England/The British Society for Disability and Oral Health The oral management of oncology patients requiring radiotherapy, chemotherapy and/or bone marrow transplantation—clinical guidelines 2012. https://www.rcseng.ac.uk/-/media/files/rcs/fds/publications/oncology-guidelines-october-2012.pdf

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ronnie Levine
    • 1
  • Catherine Stillman-Lowe
    • 2
  1. 1.Department of Oral SurgeryUniversity of LeedsLeedsUK
  2. 2.ReadingUK

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