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Research: Clinical, Basic, and Translational

  • Dennis V. CokkinosEmail author
Chapter

Abstract

Research is an indispensable tool for achieving scientific progress. There are many definitions of research, basic, clinical, and translational research. A very practical and short definition of translational research could be the application of findings from basic research to patient, community, and population care and to the advancement of the delivery of health services.

Usually three steps can be defined:
  • T1 (T for translation) is the transfer of new understanding of disease mechanisms gained in the laboratory into the development of new methods for diagnosis and therapy.

  • T2 is the translation of results from clinical studies into everyday clinical practice and health decision-making.

  • T3 is the dissemination and implementation of research translation into practice/community/large populations. Up to six steps have been proposed.

Corresponding blocks or impediments are delineated to the successful employment of these steps. A newly introduced concept is the Valley of Death, describing the difficulty of research results to reach successful innovation application.

The foundation and collaboration of centers able to conduct translational research, such as the National Institutes of Health and the National Clinical and Translational Science Award Consortium, have helped progress.

The teaching, training and formation of translational researchers are difficult, varied, and a matter of constant effort.

To overcome increasing costs, the combination of “wet,” i.e., biological labs with “dry” or computational data, is being increasingly employed. However, their integration and coordination are very important.

Keywords

Clinical research Translational research Research Basic Research Valley of Death Dry lab Wet lab Blocks to research 

References

  1. 1.
    Coller BS. Translating from the rivers of Babylon to the coronary bloodstream. J Clin Invest. 2012;122:4293–9.PubMedPubMedCentralCrossRefGoogle Scholar
  2. 2.
    Fox KA, Steg PG, Eagle KA, Goodman SG, Anderson FA Jr, Granger CB, et al. Decline in rates of death and heart failure in acute coronary syndromes, 1999–2006. JAMA. 2007;297:1892–9.PubMedCrossRefPubMedCentralGoogle Scholar
  3. 3.
    van der Laan AL, Boenink M. Beyond bench and bedside: disentangling the concept of translational research. Health Care Anal. 2015;23:32–49.PubMedCrossRefPubMedCentralGoogle Scholar
  4. 4.
    Antoniades Ch. Bridging the gap between basic science and clinical practice: The role of translational medicine. Lecture presented at the Biomedical Research Foundation Academy of Athens, 31 October 2012.Google Scholar
  5. 5.
    Cokkinos DV. Introduction: what is translational research in: Cokkinos DV, editor. Introduction to translational cardiovascular research. 1st ed. Cham. Springer 2015;p3–16.Google Scholar
  6. 6.
    NSF. Definition of Research. National Science Foundation 2007. http://www.Nsf.gov/statistics/randdef/business.cfm.
  7. 7.
    Oxford English Dictionary (www.oed.com).
  8. 8.
    Merriam Webster, Oxford English Dictionary, Research merriam-webster.com, updated 21 May 2018.Google Scholar
  9. 9.
    Popper KR. Objective knowledge. 2nd ed. Oxford: Clarendon press; 1972. p. 191–205.Google Scholar
  10. 10.
    Jan I. Thinking about research: frameworkers, ethics and scholarships. Edinburgh: Association for the study of Medical Education; 2007. p. 2–37.Google Scholar
  11. 11.
    Bush V (ed.). Science: the endless frontier a report to the president by Vannevar Bush, Director of the Office of Scientific research and Development Washington DC. United states Government Printing office. Jul 1945. Accessed November 13, 2009. Section 3 (The importance of Basic research), Chapter 3 (Science and the public welfare). http://nsf.gov/about/history/nsf50/vbush1945_content.jsp
  12. 12.
    Hecker L, Birla RV. Intangible factors leading to success in research: strategy, innovation and leadership. J Cardiovasc Trans Res. 2008;1:85–92.CrossRefGoogle Scholar
  13. 13.
    Glossary of Themes for Human Subjects Protection and inclusion issues based on the 1997 report of the NIH Director’s Panel on clinical research, entry: “clinical research”. Accessed November 13 2009. http://grants.nih.gov/grants/peer/tree_glossary.pdf
  14. 14.
    Schteingart DE. Introduction to principles of clinical and translational research. ESCI Core Course on Clinical Research, Athens, 8–10, October 2010.Google Scholar
  15. 15.
    NIH National Cancer Institute NCI Dictionary of Cancer Terms.Google Scholar
  16. 16.
    Seely WE, Grinspoon S. Patient-oriented research: clinical pathophysiology and clinical therapeutics. In: Robertson D, Williams GH, editors. Clinical and translational science. 1st ed. London: Elsevier; 2009. p. 3–12.CrossRefGoogle Scholar
  17. 17.
    U.S. Department of Health and Human Services. U.S Food and Drug Administration. What Are the Different Types of Clinical Research?Google Scholar
  18. 18.
    Califf RM, Zarin DA, Kramer JM, Sherman RE, Aberle LH, Tasneem A. Characteristics of clinical trials registered in ClinicalTrials.gov, 2007–2010. JAMA. 2012;307:1838–47.PubMedCrossRefGoogle Scholar
  19. 19.
    Zarin DA, Tse T, Williams RJ, Califf RM, Ide NC. The ClinicalTrials.gov results database--update and key issues. N Engl J Med. 2011;364:852–60.PubMedPubMedCentralCrossRefGoogle Scholar
  20. 20.
    Karp JE, McCaffrey RP. New avenues of translational research in leukemia and lymphoma: outgrowth of a Leukemia Society of America-National Cancer Institute workshop. J Natl Cancer Inst. 1994;86:1196–201.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Feldman AM, Koch WJ, Force TL. Developing strategies to link basic cardiovascular sciences with clinical drug development: another opportunity for translational sciences. Clin Pharmacol Ther. 2007;81:887–92.PubMedCrossRefPubMedCentralGoogle Scholar
  22. 22.
    Littman BH, Di Mario L, Plebani M, Marincola FM. What's next in translational medicine? Clin Sci (Lond). 2007;112:217–27.CrossRefGoogle Scholar
  23. 23.
    Woolf SH. The meaning of translational research and why it matters. JAMA. 2008;290:211–3.Google Scholar
  24. 24.
    Dische S, Saunders M. Translational research--a new entity? Acta Oncol. 2001;40:995–9.PubMedCrossRefPubMedCentralGoogle Scholar
  25. 25.
    Coller BS. Translational research: Forging a new cultural identity. Mt Sinai J Med. 2008;75:478–87.PubMedPubMedCentralCrossRefGoogle Scholar
  26. 26.
    Williams GH, Robertson D. Introduction to clinical research. In: Robertson D, Williams GH, editors. Clinical and translational science. 1st ed. London: Elsevier; 2009. p. xvii–xx.CrossRefGoogle Scholar
  27. 27.
    Williams GH, Robertson D. Clinical and translational science infrastructure. In: Robertson D, Williams GH, editors. Clinical and translational science. 1st ed. London: Elsevier; 2009. p. 171–81.Google Scholar
  28. 28.
    Davis D, Evans M, Jadad A, Perrier L, Rath D, Ryan D, et al. The case for knowledge translation: shortening the journey from evidence to effect. BMJ. 2003;327(7405):33–5.PubMedPubMedCentralCrossRefGoogle Scholar
  29. 29.
    National Cancer Institute. Translational Research Working Group Definition of Translational Research: http://www.cancer.gov/trwg/TRWG-definition-ND-tr-continuum.
  30. 30.
    Sung NS, Crowley WF Jr, Genel M, Salber P, Sandy L, Sherwood LM, et al. Central challenges facing the national clinical research enterprise. JAMA. 2003;289:1278–87.PubMedCrossRefPubMedCentralGoogle Scholar
  31. 31.
    Lauer M, Scarlatos S. Translational research for cardiovascular diseases at the national heart lung and blood institute. Moving from bench to bedside and from bedside to community. Circulation. 2010;121:929–33.PubMedPubMedCentralCrossRefGoogle Scholar
  32. 32.
    Westfall JM, Mold J, Fagnan L. Practice-based research--"Blue Highways" on the NIH roadmap. JAMA. 2007;297:403–6.PubMedCrossRefPubMedCentralGoogle Scholar
  33. 33.
    Malliaras K, Kreke M, Marbán E. The stuttering progress of cell therapy for heart disease. Clin Pharmacol Ther. 2011;90:532–41.PubMedCrossRefPubMedCentralGoogle Scholar
  34. 34.
    Waldman SA, Terzic A. Clinical and translational science: from bench-bedside to global village. Clin Transl Sci. 2010;5:254–7.CrossRefGoogle Scholar
  35. 35.
    McGarland R, Schoenbaum E, Lee S, Schteinggard DE, Marantz PR, Anderson KE, et al. Defining translational research: implications for training. Acad Med. 2010;85:470–5.CrossRefGoogle Scholar
  36. 36.
    Koch WJ. Targeting the beta-adrenergic receptor kinase in heart failure. Lecture presented at the 1st International Scientific Conference on Cardiovascular biotechnology: From cell to man, Biomedical Research Foundation of the Academy of Athens. 31 May 2013.Google Scholar
  37. 37.
    Kieburtz K, Olanow CW. Translational experimental therapeutics: the translation of laboratory-based discovery into disease-related therapy. Mt Sinai J Med. 2007;74:7–14.PubMedCrossRefPubMedCentralGoogle Scholar
  38. 38.
    Murry CE, Jennings KA, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74:1124–36.PubMedCrossRefPubMedCentralGoogle Scholar
  39. 39.
    Seals DR. Translational physiology: from molecules to public health. J Physiol. 2013;591:3457–69.PubMedPubMedCentralCrossRefGoogle Scholar
  40. 40.
    Seals DR, Kaplon RE, Gioscia-Ryan RA, TJ LR 2nd. You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology (Bethesda). 2014;29:250–64.Google Scholar
  41. 41.
    Khoury MJ, Gwinn M, Ioannidis JP. The emergence of translational epidemiology: from scientific discovery to population health impact. Am J Epidemiol. 2010;172:517–24.PubMedPubMedCentralCrossRefGoogle Scholar
  42. 42.
    Brück K, Stel VS, Fraser S, De Goeij MC, Caskey F, Abu-Hanna A, et al. Translational research in nephrology: chronic kidney disease prevention and public health. Clin Kidney J. 2015;8:647–55.PubMedPubMedCentralCrossRefGoogle Scholar
  43. 43.
    Kasim-Karakas S, Hyson D, Halsted C, van Loan M, Chedin E, Berglund L. Translational nutrition research at UC Davis--the key role of the Clinical and Translational Science Center. Ann N Y Acad Sci. 2010;1190:179–83.PubMedPubMedCentralCrossRefGoogle Scholar
  44. 44.
    Iwashyna TJ, Liu V. What's so different about big data? A primer for clinicians trained to think epidemiologically. Ann Am Thorac Soc. 2014;11:1130–5.PubMedPubMedCentralCrossRefGoogle Scholar
  45. 45.
    Christodoulakis A, Karanikas H, Billiris A, Thireos E, Pelekis N. “Big data” in health care Assessment of the performance of Greek NHS Hospitals using key performance and clinical workload indicators. Arch Hellenic Med. 2016;33:489–97.Google Scholar
  46. 46.
    Trochim W. Evaluating translational science. Presentation to the Cornell Evaluation Network Presentation to the Cornell Evaluation Network September 29, 2008.Google Scholar
  47. 47.
    Hostiuc S, Moldoveanu A, Dascălu MI, Unnthorsson R6, Jóhannesson ÓI, Marcus I. Translational research-the need of a new bioethics approach. J Transl Med. 2016;14:16.  https://doi.org/10.1186/s12967-016-0773-4.CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Athey BD, Braxenthaler M, Haas M, Guo Y. tranSMART: an open source and community-driven informatics and data sharing platform for clinical and translational research. AMIA J Summits Transl Sci Proc. 2013;2013:6–8.Google Scholar
  49. 49.
    Malin B, Karp D, Scheuermann RH. Technical and policy approaches to balancing patient privacy and data sharing in clinical and translational research. J Investig Med. 2010;58:11–8.PubMedPubMedCentralCrossRefGoogle Scholar
  50. 50.
    Chautard E, Thierry-Mieg N, Ricard-Blum S. Interaction networks: from protein functions to drug discovery. A review. Pathol Biol (Paris). 2009;57:324–33.CrossRefGoogle Scholar
  51. 51.
    National Cancer Institute: research dissemination and diffusion. Nov 47, 2007.Google Scholar
  52. 52.
    Zucker DR. What is needed to promote translational research and how do we get it? J Investig Med. 2009;57:468–70.PubMedCrossRefGoogle Scholar
  53. 53.
    Bernard GR. Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS.). Clin Transl Sci. 2012;5:121–9.PubMedCrossRefGoogle Scholar
  54. 54.
    Hartmann KE, Heitman E, Brown NJ. Training basic, clinical and translational investigators. In: Robertson D, Williams GH, editors. Clinical and translational science. 1st ed. London: Elsevier; 2009. p. 191–9.CrossRefGoogle Scholar
  55. 55.
    Pienta KJ. Successfully accelerating translational research at an academic medical center: the University of Michigan-Coulter translational research partnership program. Clin Transl Sci. 2010;3:316–8.PubMedPubMedCentralCrossRefGoogle Scholar
  56. 56.
    Mata HJ, Davis S. Translational health research: perspectives from health education specialists. Clin Transl Med. 2012;1:27.PubMedPubMedCentralCrossRefGoogle Scholar
  57. 57.
    Williams GH, Robertson D. The future of clinical research. In: Robertson D, Williams GH, editors. Clinical and translational science. 1st ed. London: Elsevier; 2009. p. 565–70.CrossRefGoogle Scholar
  58. 58.
    Nadler LM, Roberts WC. Lee Marshall Nadler, MD: a conversation with the editor. Proc Bayl Univ Med Cent. 2007;20:381–9.PubMedPubMedCentralCrossRefGoogle Scholar
  59. 59.
    Verkoeijen PPJL, Tabbers HK. Good research requires productive theories and guidelines. Med Educ. 2013;47:858–65.CrossRefGoogle Scholar
  60. 60.
    Pang T, Terry RF, The PLoS Medicine Editors WHO/PLoS Collection. No health without research: a call for papers. PLoS Med, 4 e1001008. 2011;8Google Scholar
  61. 61.
    White KL, Williams TF, Greenberg BG. The ecology of medical care. N Engl J Med. 1961;265:885–92.PubMedCrossRefPubMedCentralGoogle Scholar
  62. 62.
    Green LA, Fryer GE Jr, Yawn BP, Lanier D, Dovey SM. The ecology of medical care revisited. N Engl J Med. 2001;344:2021–5.PubMedCrossRefPubMedCentralGoogle Scholar
  63. 63.
    Martin SS, Ou FS, Newby LK, Sutton V, Adams P, Felker GM, Wang TY. Patient- and trial-specific barriers to participation in cardiovascular randomized clinical trials. J Am Coll Cardiol. 2013;61:762–9.PubMedCrossRefPubMedCentralGoogle Scholar
  64. 64.
    Brutsaert D. Heart Failure: Quo Vadis Lecture presented at Cardiovascular Biotechnology: From cell to man Biomedical Research Foundation Academy of Athens, 31 May – 1 June 2013.Google Scholar
  65. 65.
    Califf RM. Clinical trials. In: Robertson D, Williams GH, editors. Clinical and translational science. 1st ed. London: Elsevier; 2009. p. 13–37.CrossRefGoogle Scholar
  66. 66.
    Moss AJ, Francis CW, Rayan D. Collaborative clinical trials. N Engl J Med. 2011;364:789791.CrossRefGoogle Scholar
  67. 67.
    Welke KF, Ferguson TB Jr, Cooms LP, Dokholygan RS, Murray CJ, Sehrader MI, et al. Validity of the society of thoracic surgeons national adult cardiac surgery database. Ann Thorac Surg. 2004;77:1137–9.PubMedCrossRefPubMedCentralGoogle Scholar
  68. 68.
    Sipido KR, Casadei B, Holvoet P, Janssens S, Luttun A, Sampaolesi M. Bedside to bench: a look at experimental research with a clinical trial checklist. Cardiovasc Res. 2014;101:1–3.PubMedPubMedCentralCrossRefGoogle Scholar
  69. 69.
    Kaul S, Diamond GA. Trial and error. How to avoid commonly encountered limitations of published clinical trials. J Am Coll Cardiol. 2010;55:415–27.PubMedCrossRefPubMedCentralGoogle Scholar
  70. 70.
    Benson K, Hartz AJ. A comparison of observational studies and randomized, controlled trials. N Engl J Med. 2000;342:1878–86.PubMedCrossRefPubMedCentralGoogle Scholar
  71. 71.
    Chalmers TC, Celano P, Sacks HS, Smith H Jr. Bias in treatment assignment in controlled clinical trials. N Engl J Med. 1983;309:1358–61.PubMedCrossRefPubMedCentralGoogle Scholar
  72. 72.
    Tricoci P, Allen JM, Kramer JM, Califf RM, Smith SC Jr. Scientific evidence underlying the ACC/AHA clinical practice guidelines. JAMA. 2009;301:831–41.PubMedCrossRefPubMedCentralGoogle Scholar
  73. 73.
    O'Neil M, Berkman N, Hartling L, Chang S, Anderson J, Motu'apuaka M, et al. Observational evidence and strength of evidence domains: case examples. Syst Rev. 2014;3:35.  https://doi.org/10.1186/2046-4053-3-35.CrossRefPubMedPubMedCentralGoogle Scholar
  74. 74.
    Mentz RJ, Kelly JP, von Lueder TG, Voors AA, Lam CS, Cowie MR, et al. Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction. J Am Coll Cardiol. 2014;64:2281–93.PubMedPubMedCentralCrossRefGoogle Scholar
  75. 75.
    D'Agostino RB. Jr. Propensity scores in cardiovascular research. Circulation. 2007;115:2340–3.PubMedCrossRefPubMedCentralGoogle Scholar
  76. 76.
    Martens EP, Pestman WR, de Boer A, Belitser SV, Klungel OH. Systematic differences in treatment effect estimates between propensity score methods and logistic regression. Int J Epidemiol. 2008;37:1142–7.PubMedCrossRefPubMedCentralGoogle Scholar
  77. 77.
    Gitt AK, Bueno H, Danchin N, Fox K, Hochadel M, Kearney P, et al. The role of cardiac registries in evidence-based medicine. Eur Heart J. 2010;31:525–9.PubMedCrossRefPubMedCentralGoogle Scholar
  78. 78.
    Lenzen MJ, Boersma E, Reimer WJ, Balk AH, Komajda M, Swedberg K, et al. Under-utilization of evidence-based drug treatment in patients with heart failure is only partially explained by dissimilarity to patients enrolled in landmark trials: a report from the Euro Heart Survey on Heart Failure. Eur Heart J. 2005;26:2706–13.PubMedCrossRefPubMedCentralGoogle Scholar
  79. 79.
    Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF, et al. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. Am Heart J. 2003;146:250–7.PubMedCrossRefPubMedCentralGoogle Scholar
  80. 80.
    James S, Fröbert O, Lagerqvist B. Cardiovascular registries: a novel platform for randomised clinical trials. Heart. 2012;98:1329–231.PubMedCrossRefGoogle Scholar
  81. 81.
    Lauer MS, D'Agostino RB Sr. The randomized registry trial--the next disruptive technology in clinical research? N Engl J Med. 2013;369:1579–81.PubMedCrossRefPubMedCentralGoogle Scholar
  82. 82.
    Fröbert O, Lagerqvist B, Gudnason T, Thuesen L, Svensson R, Olivecrona GK, et al. Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia (TASTE trial). A multicenter, prospective, randomized, controlled clinical registry trial based on the Swedish angiography and angioplasty registry (SCAAR) platform. Study design and rationale. Am Heart J. 2010;160:1042–8.PubMedCrossRefPubMedCentralGoogle Scholar
  83. 83.
    James S, Rao SV, Granger CB. Registry-based randomized clinical trials--a new clinical trial paradigm. Nat Rev Cardiol. 2015;12:312–6.PubMedCrossRefPubMedCentralGoogle Scholar
  84. 84.
    Olsen SF, Østerdal ML, Salvig JD, Mortensen LM, Rytter D, Secher NJ, et al. Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am J Clin Nutr. 2008;88:167–75.PubMedCrossRefPubMedCentralGoogle Scholar
  85. 85.
    Balas EA, Boren SA. In: Balas EA, editor. Yearbook of medical informatics: managing clinical knowledge for health care improvement. Stuttgart: Shattauer Verlagsgesellschaft mbH; 2000. p. 65–70.Google Scholar
  86. 86.
    Contopoulos-Ioannidis DG, Alexiou GA, Grouvias TC, Ioannidis JPA. Life circle of translational research for medical interventions. Science. 2008;321:1298–9.PubMedCrossRefPubMedCentralGoogle Scholar
  87. 87.
    Morris ZS, Wooding S, Grant J. The answer is 17 years, what is the question: understanding time lags in translational research. J R Soc Med. 2011;104:510–20.PubMedPubMedCentralCrossRefGoogle Scholar
  88. 88.
    Altman DG, Goodman SN. Transfer of technology from statistical journals to the biomedical literature. Past trends and future predictions. JAMA. 1994;272:129–32.PubMedCrossRefPubMedCentralGoogle Scholar
  89. 89.
    Young D, Borland R. Conceptual challenges in the translation of research into practice: it's not just a matter of "communication". Transl Behav Med. 2011;1:256–69.PubMedPubMedCentralCrossRefGoogle Scholar
  90. 90.
    Cribier A. Development of transcatheter aortic valve implantation (TAVI): a 20-year odyssey. Arch Cardiovasc Dis. 2012;105:146–52.PubMedCrossRefPubMedCentralGoogle Scholar
  91. 91.
    Cribier A, Eltchaninoff H, Tron C, Bauer F, Agatiello C, Nercolini D, et al. Treatment of calcific aortic stenosis with the percutaneous heart valve: mid-term follow-up from the initial feasibility studies: the French experience. J Am Coll Cardiol. 2006;47:1214–23.PubMedCrossRefPubMedCentralGoogle Scholar
  92. 92.
    Farnier M. PCSK9: from discovery to therapeutic applications. Arch Cardiovasc Dis. 2014;107:58–66.PubMedCrossRefPubMedCentralGoogle Scholar
  93. 93.
    Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, et al. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci U S A. 2003;100:928–33.PubMedPubMedCentralCrossRefGoogle Scholar
  94. 94.
    Stein EA, Mellis S, Yancopoulos GD, Stahl N, Logan D, Smith WB, et al. Effect of a monoclonal antibody to PCSK9 on LDL cholesterol. N Engl J Med. 2012;366:1108–18.PubMedCrossRefGoogle Scholar
  95. 95.
    Hudson J, Khazhragui HF. Into the valley of death; research to innovation. Drug Discov Today. 2012;18:610–3.CrossRefGoogle Scholar
  96. 96.
    Butler D. Translational research; crossing the valley of death. Nature. 2008;453:840–2.PubMedCrossRefGoogle Scholar
  97. 97.
    Roberts SF, Fischhoff MA, Sakowski SA, Feldman EL. Perspective: Transforming science into medicine: how clinician-scientists can build bridges across research's "valley of death". Acad Med. 2012;87:266–70.PubMedCrossRefGoogle Scholar
  98. 98.
    Coller BS, Califf RM. Traversing the valley of death: a guide to assessing prospects for translational success. Sci Transl Med. 2009;1:10cm9.  https://doi.org/10.1126/scitranslmed.3000265.CrossRefPubMedPubMedCentralGoogle Scholar
  99. 99.
    Bodi V, Marrachelli VG, Husser O, Chorro FJ, Viña JR, Monleon D. Metabolomics in the diagnosis of acute myocardial ischemia. J Cardiovasc Trans Res. 2013;6:808–15.CrossRefGoogle Scholar
  100. 100.
    Moses H 3rd, Dorsey ER, Matheson DH, Their SO. Financial anatomy of biomedical research. JAMA. 2005;294:1333–42.PubMedCrossRefPubMedCentralGoogle Scholar
  101. 101.
    Merton RK. The Matthew effect in science: the reward and communication systems of science are considered. Science. 1968;159:56–63.CrossRefGoogle Scholar
  102. 102.
    Quinn T, Kohl P. Combining wet and dry research: experience with model development for cardiac mechano-electric structure-function studies. Cardiovasc Res. 2013;97:601–11.PubMedPubMedCentralCrossRefGoogle Scholar
  103. 103.
    Garny A, Noble D. Dimensionality in cardiac modelling. Prog Biophys Mol Biol. 2005;87:47–66.PubMedCrossRefPubMedCentralGoogle Scholar
  104. 104.
    The Royal Swedish Academy of Science. Taking permission the experiment to cyberspace. Popular science background. Nobel prize in Chemistry, 2013.Google Scholar
  105. 105.
    Hudson J, Khazragui HF. Into the valley of death: research to innovation. Drug Discov Today. 2013;18:610–3.PubMedCrossRefPubMedCentralGoogle Scholar
  106. 106.
    Curry SH. Translational science: past, present, and future. Bio Techniques. 2008;44:Pii–Pviii.Google Scholar
  107. 107.
    Braunwald E. Cardiovascular science: opportunities for translating research into improved care. J Clin Invest. 2013;123:6–10.PubMedPubMedCentralCrossRefGoogle Scholar
  108. 108.
    Stamler JS, Taber RL, Califf RM. Translation of academic discovery into societal benefit: proposal for a balanced approach--part 1. Am J Med. 2003;115:596–9.PubMedCrossRefPubMedCentralGoogle Scholar
  109. 109.
    Mann DL. Mr. Can. Trump make translational research great again? JACC: Basic to Translational Science. 2017;2:1.  https://doi.org/10.1016/j.jacbts.2017.01.001.PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Heart and Vessel DepartmentBiomedical Research Foundation, Academy of Athens - Gregory SkalkeasAthensGreece

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