The Role of Chemokines in Fibrotic Dermal Remodeling and Wound Healing

  • Zariel I. Johnson
  • Christopher Mahoney
  • Jun Heo
  • Erin Frankel
  • Dana R. Julian
  • Cecelia C. YatesEmail author
Part of the Molecular and Translational Medicine book series (MOLEMED)


The skin is an essential part of the integumentary organ system, providing protection from pathogens, allowing for water and electrolyte homeostasis, and relaying sensory information from the surroundings. Skin has a sophisticated and orderly architecture of dermal layers, each containing a unique mixture of cell populations, specialized structures, and extracellular matrix components. Following wounding, the dermis undergoes a highly ordered process of repair that consists of overlapping phases of hemostasis and inflammation, proliferation and angiogenesis, and remodeling of the nascent tissue. The activities of chemokines largely orchestrate this healing process. These small cytokines act through various receptors and effects on the extracellular matrix to coordinate migration, survival, and other cellular processes. Several of these chemokine signaling pathways influence the inflammatory cascade early on in healing and the later growth and regression of neovasculature, re-epithelializaiton of the wound area, and ultimately are essential for providing cues when the repair process should halt the process is complete.


Dermal wound healing Chemokines Fibrosis Remodeling Inflammation Re-epithelialization 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Zariel I. Johnson
    • 1
  • Christopher Mahoney
    • 2
  • Jun Heo
    • 1
  • Erin Frankel
    • 1
  • Dana R. Julian
    • 1
  • Cecelia C. Yates
    • 1
    • 3
    Email author
  1. 1.Department of Health Promotion and DevelopmentUniversity of Pittsburgh School of NursingPittsburghUSA
  2. 2.Department of BioengineeringUniversity of Pittsburgh Swanson School of EngineeringPittsburghUSA
  3. 3.McGowan Institute for Regenerative MedicineUniversity of PittsburghPittsburghUSA

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