Alternative Corneal Cross-Linking Agents

  • Arie L. Marcovich


Corneal cross-linking can be performed by chromophores that produce reactive oxygen radicals when exposed to illumination at a specific wavelength or chemically without light application. The clinically applied and most widely studied is riboflavin that is activated by UVA light. Other chromophores under investigation are Rose Bengal and Eosin Y which are excited by green light and WST-D that is activated by near infrared light. Agents that induce cross-linking chemically are Genipin and Galacorin.


Corneal stiffening Cross-linking Ultraviolet A Green light Near infrared light 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Arie L. Marcovich
    • 1
    • 2
  1. 1.Department of OphthalmologyKaplan Medical CenterRehovotIsrael
  2. 2.Department of Plant and Environmental SciencesWeizmann Institute of ScienceRehovotIsrael

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