Pathophysiology and Diagnosis of Meniere’s Disease

  • Alexander L. LuryiEmail author
  • Elliot Morse
  • Elias Michaelides


Meniere’s disease (MD) consists of a tetrad of episodic vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness. The episodic vertigo typically resolves over time; however, hearing loss usually becomes permanent with disease progression. MD is thought to be caused by endolymphatic hydrops, which has been visualized both in pathologic temporal bone specimens and in vivo via magnetic resonance imaging. Multiple theories exist regarding the etiology of endolymphatic hydrops and the mechanism by which endolymphatic hydrops causes the symptoms of MD. MD is principally diagnosed based on clinical assessment and audiometric documentation of hearing loss; however, a variety of adjunct vestibular tests can be used to differentiate MD from similar disorders.


Meniere’s disease Endolymphatic hydrops Hearing loss Vertigo Tinnitus Vestibular testing 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Alexander L. Luryi
    • 1
    Email author
  • Elliot Morse
    • 1
  • Elias Michaelides
    • 1
  1. 1.Department of SurgeryYale University School of MedicineNew HavenUSA

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