Anatomy and Physiology of the Vestibular System

  • Ashley C. Zaleski-King
  • Wanda Lai
  • Alex D. SweeneyEmail author


The human vestibular system facilitates proper balance by sensing and integrating movement. In general, vestibular anatomy and physiology can be divided into peripheral and central components. This chapter summarizes the structural organization and the physiological processes relevant to the functioning of the vestibular system in healthy individuals.


Ampullofugal Ampullopetal Lateral vestibulospinal tract (LVST) Medial longitudinal fasciculus (MLF) Medial vestibulospinal tract (MVST) Otolith Semicircular canal (SCC) Vestibular nuclei (VN) Vestibuloocular reflex (VOR) Vestibulospinal reflex (VSR) 


  1. 1.
    Baloh RW, Honrubia V. Clinical neurophysiology of the vestibular system. New York: Oxford University Press; 2001.Google Scholar
  2. 2.
    Barin K, Durrant JD. Applied physiology of the vestibular system. In: Canalis RF, Lempert PR, editors. The ear: comprehensive otology. Philadelphia: Lippincott Williams & Wilkins; 2000. p. 431–46.Google Scholar
  3. 3.
    Barrett KE, Barman SM, Boitano S, Brooks HL. Chapter 10. Hearing & equilibrium. In: Barrett KE, Barman SM, Boitano S, Brooks HL, editors. Ganong’s review of medical physiology. 24th ed. New York: McGraw-Hill; 2012.Google Scholar
  4. 4.
    Brandt T, Dieterich M. The vestibular cortex: its locations, functions, and disorders. Ann N Y Acad Sci. 1999;871(1):293–312.CrossRefGoogle Scholar
  5. 5.
    Brodal A. Anatomy of the vestibular nuclei and their connections. In: Kornhuber HH, editor. Vestibular system part 1: basic mechanisms. Berlin: Springer; 1974. p. 239–352.CrossRefGoogle Scholar
  6. 6.
    Bronstein AM, Gresty MA. Short latency compensatory eye movement responses to transient linear head acceleration: a specific function of the otolith-ocular reflex. Exp Brain Res. 1988;71(2):406–10.CrossRefGoogle Scholar
  7. 7.
    Collewijn H, Smeets JB. Early components of the human vestibulo-ocular response to head rotation: latency and gain. J Neurophysiol. 2000;84(1):376–89.CrossRefGoogle Scholar
  8. 8.
    Corrales CE, Mudry A. History of the endolymphatic sac: from anatomy to surgery. Otol Neurotol. 2017;38(1):152–6.CrossRefGoogle Scholar
  9. 9.
    Della Santina CC, Potyagaylo V, Migliaccio AA, Minor LB, Carey JP. Orientation of human semicircular canals measured by three-dimensional multiplanar CT reconstruction. J Assoc Res Otolaryngol. 2005;6(3):191–206.CrossRefGoogle Scholar
  10. 10.
    Ezure K, Sasaki S. Frequency-response analysis of vestibular-induced neck reflex in cat. I. Characteristics of neural transmission from horizontal semicircular canal to neck motoneurons. J Neurophysiol. 1978;41(2):445–58.CrossRefGoogle Scholar
  11. 11.
    Ferrè ER, Walther LE, Haggard P. Multisensory interactions between vestibular, visual and somatosensory signals. PLoS One. 2015;10(4):e0124573.CrossRefGoogle Scholar
  12. 12.
    Fernandez C, Goldberg JM. Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey. II. Response to sinusoidal stimulation and dynamics of peripheral vestibular system. J Neurophysiol. 1971;34(4):661–75.CrossRefGoogle Scholar
  13. 13.
    Fernandez C, Goldberg JM. Physiology of peripheral neurons innervating otolith organs of the squirrel monkey. I. Response to static tilts and to long-duration centrifugal force. J Neurophysiol. 1976;39(5):970–84.CrossRefGoogle Scholar
  14. 14.
    Guldin WO, Grüsser OJ. Is there a vestibular cortex? Trends Neurosci. 1998;21(6):254–9.CrossRefGoogle Scholar
  15. 15.
    Hain TC, Helminski JO. Anatomy and physiology of the normal vestibular system. In: Herman SJ, editor. Vestibular rehabilitation. Philadelphia: F.A. Davis Company; 2007.Google Scholar
  16. 16.
    Highstein SM, Fay RR, Popper AN. The vestibular system, vol. 24. Berlin: Springer; 2004. p. 154–6.CrossRefGoogle Scholar
  17. 17.
    Horak FB, Shupert CL. Role of the vestibular system in postural control. Vestib Rehabil. 1994;2:98–113.Google Scholar
  18. 18.
    Johnston JL, Sharpe JA. The initial vestibulo-ocular reflex and its visual enhancement and cancellation in humans. Exp Brain Res. 1994;99(2):302–8.CrossRefGoogle Scholar
  19. 19.
    Precht W. Labyrinthine influences on the vestibular nuclei. Progress in Brain Research. 1979; 50: 369–381.Google Scholar
  20. 20.
    Khan S, Chang R. Anatomy of the vestibular system: a review. NeuroRehabilitation. 2013;32(3):437–43.PubMedGoogle Scholar
  21. 21.
    Laurens J, Angelaki DE. The functional significance of velocity storage and its dependence on gravity. Exp Brain Res. 2011;210(3–4):407–22.CrossRefGoogle Scholar
  22. 22.
    Lee SC, Abdel Razek OA, Dorfman BE. Vestibular system anatomy. 2011. Retrieved from: aw2aab6c10.
  23. 23.
    Lyskowski A. Anatomy of vestibular end organs and neural pathways. In: Cummings CW, et al., editors. Otolaryngology – head & neck surgery. Philadelphia: Elsevier Mosby; 2005. p. 3089–114.Google Scholar
  24. 24.
    Kingma H. Function tests of the otolith of statolith system. Curr Opin Neurol. 2006; 19(1): 21–5.CrossRefGoogle Scholar
  25. 25.
    Markham CH, Diamond SG. Ocular counterrolling in response to static and dynamic tilting: implications for human otolith function. J Vestib Res. 2003;12:127–34.Google Scholar
  26. 26.
    Mescher AL. Chapter 23. The eye and ear: special sense organs. In: Mescher AL, editor. Junqueira’s basic histology: text & atlas. 12th ed; McGraw-Hill Medical, New York. 2010.Google Scholar
  27. 27.
    Oghalai JS, Brownell WE. Chapter 44. Anatomy & physiology of the ear. In: Lalwani AK, editor. Current diagnosis & treatment in otolaryngology—head & neck surgery. 3th ed; McGraw-Hill Medical, New York. 2012.Google Scholar
  28. 28.
    Paige GD, Tomko DL. Eye movement responses to linear head motion in the squirrel monkey. I. basic characteristics. J Neurophysiol. 1991;65(5):1170–82.CrossRefGoogle Scholar
  29. 29.
    Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia AS, McNamara JO, White LE. Neuroscience. 4th ed. Sunderland: Sinauer Associates; 2012.Google Scholar
  30. 30.
    Salt AN. The cochlear fluids: perilymph and endolymph. In: Altschuler RA, Hoffman DW, Bobbin RP, editors. Neurobiology of hearing: the cochlea. New York: Raven Press; 1986. p. 109–22.Google Scholar
  31. 31.
    Shinder ME, Taube JS. Differentiating ascending vestibular pathways to the cortex involved in spatial cognition. J Vestib Res. 2010;20(1, 2):3–23.Google Scholar
  32. 32.
    Ten Donkelaar HJ. Descending pathways from the brain stem to the spinal cord in some reptiles. II. Course and site of termination. J Comp Neurol. 1976;167(4):443–63.CrossRefGoogle Scholar
  33. 33.
    Lopez C, Blanke O. The thalamocortical vestibular system in animals and humans. Brain Res Rev. 2011; 67(1-2):119–46.CrossRefGoogle Scholar
  34. 34.
    Shinder ME, Newlands SD. Sensory convergence in the parieto-insular vestibular cortex. J Neurophysiol. 2014;111(12):2445–64.CrossRefGoogle Scholar
  35. 35.
    Uchino Y, Ikegami H, Sasaki M, Endo K, Imagawa M, Isu N. Monosynaptic and disynaptic connections in the utriculo-ocular reflex arc of the cat. J Neurophysiol. 1994;71(3):950–8.CrossRefGoogle Scholar
  36. 36.
    Wong A. Eye movement disorders. New York: Oxford University Press; 2008.Google Scholar
  37. 37.
    Zingler VC, Kryvoshey D, Schneider E, Glasauer S, Brandt T, Strupp M. A clinical test of otolith function: static ocular counter-roll with passive head tilt. Neuroreport. 2006;17(6):611–5.CrossRefGoogle Scholar
  38. 38.
    Zupan LH, Merfeld DM. Neural processing of gravito-inertial cues in humans. IV. Influence of visual rotational cues during roll optokinetic stimuli. J Neurophysiol. 2003;89(1):390–400.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ashley C. Zaleski-King
    • 1
  • Wanda Lai
    • 2
  • Alex D. Sweeney
    • 3
    Email author
  1. 1.Audiology and Speech Center, Walter Reed National Military Medical CenterBethesdaUSA
  2. 2.Department of NeurotologyProvidence Hospital, Michigan Ear InstituteFarmington HillsUSA
  3. 3.Baylor College of Medicine and Texas Children’s HospitalHoustonUSA

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