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IgA Nephropathy

  • Aris Oates
Chapter

Abstract

IgAN, once thought to be a benign entity in children and adults, is a common cause of glomerulonephritis worldwide and a major cause of ESRD. In this chapter we review the worldwide epidemiology of the disease in adolescents and children to explore the pathologic and histologic defining features. Consensus diagnosis and treatment options are discussed. Established as a slowly progressive disease with variable course, close follow-up, and optimized supportive care is recommended in patients without severe disease to help improve renal survival. Investigations into the optimal subset of patients to benefit from immunosuppressive therapy and new treatment targets are ongoing.

Keywords

Immunoglobulin A Glomerulonephritis Immune complex nephropathy Mesangial deposits Macroscopic hematuria End-stage renal disease 

Abbreviations

ESRD

End-stage renal disease

GWAS

Genome-wide association studies

IgAN

Immunoglobulin A nephropathy

KDIGO

Kidney disease improving global outcomes

Notes

Acknowledgments

The authors wish to thank Dr. Zoltan Laszik for the pathology images in Figs. 7.1, 7.2, and 7.3.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.University of CaliforniaSan FranciscoUSA

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