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Immunosuppressive Medications in Kidney Transplantation

  • Lavjay Butani
Chapter

Abstract

While acute rejection and short-term graft survival have improved in the modern era of renal transplantation, gains in long-term graft survival have been more limited. This is, in part, due to the nephrotoxic effect of many posttransplant medications, such as the calcineurin inhibitors. Moreover, side effects of other immunosuppressive medications such as corticosteroids have contributed to significant morbidity and mortality, especially from their effects on cardiovascular health. The past two decades have seen much innovation in the use of immunosuppressive strategies to facilitate minimal exposure to these potent but potentially toxic medications. This chapter discusses some of the common immunosuppressive medications and strategies that are being used for induction and maintenance therapy in children and adolescents following transplantation.

Keywords

Transplantation Steroid minimization Induction Maintenance Pediatric Rejection 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of PediatricsUniversity of California Davis Medical CenterSacramentoUSA

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