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Potential Use of Plant Proteolytic Enzymes in Hemostasis

  • Alfonso Pepe
  • María Gabriela Guevara
  • Florencia Rocío Tito
Chapter

Abstract

Hemostasis is defined as the maintenance of the fluidity of circulating blood while at the same time protecting the organism from life-threatening bleeding at sites of vascular injury. The cell-mediated system of proteolysis of plasma coagulation proteins is essential for the survival of the organism. The hemostatic mechanism has evolved as a complex system in which serine proteases with high specificity assemble on cell membrane receptors in complex with cofactor molecules. They propagate several enzymatic reactions that lead to the formation of a thrombus that stop bleedings. It can be divided into the processes of platelet plug formation, blood coagulation, anticoagulation, and fibrinolysis (Walsh and Ahmad 2002).

Keywords

Pro-coagulants Anticoagulant activity Fibrinolytic activity Fibrin(ogen)olytic activity 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Biological Research Institute, National Council of Scientific and Technique Research (CONICET)University of Mar del Plata (UNMDP)Mar del PlataArgentina

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