This chapter outlines the effects pregnancy has on the hepatic system. It addresses the changes in hepatic laboratory tests, such as AST, ALT, and ALP. It also discusses gallbladder disease during pregnancy.
KeywordsBilirubin ALT and AST Lactic dehydrogenase ALP Gallbladder disease
Liver size, morphology , and blood flow do not change
Bilirubin, ALT, AST, and lactic dehydrogenase are upper limits of normal during pregnancy
ALP increases 2–4× due to production from placenta
Increased risk of gallbladder disease during pregnancy due to the inhibitory effects of progesterone on GI smooth muscles, leading to gallbladder hypomotility and subsequent biliary stasis