Barrier Function

  • Cassandra Wasson
  • Albert Kelly
  • David Ninan
  • Quy Tran


This chapter discusses the barrier function of the placenta. It discusses how the placental decreases fetal drug exposure.


Imperfect barrier Cytochrome P-450 isoenzymes Metabolize agents Bind substances Fetal drug exposure 
  1. 1.

    The placenta is an imperfect barrier (allows many substances to cross)

  2. 2.
    Cytochrome P-450 isoenzymes are located in the placenta, and some may be inducible
    1. (a)

      These enzymes may metabolize agents and decrease fetal exposure

  3. 3.

    Placenta may also bind substances to minimize fetal exposure to and accumulation of substances


Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Cassandra Wasson
    • 1
  • Albert Kelly
    • 1
  • David Ninan
    • 2
  • Quy Tran
    • 3
  1. 1.Riverside University Health System - Medical CenterMoreno ValleyUSA
  2. 2.Riverside University Health System - Medical CenterLoma LindaUSA
  3. 3.Harbor–UCLA Medical CenterTorranceUSA

Personalised recommendations