This chapter discusses the barrier function of the placenta. It discusses how the placental decreases fetal drug exposure.
KeywordsImperfect barrier Cytochrome P-450 isoenzymes Metabolize agents Bind substances Fetal drug exposure
The placenta is an imperfect barrier (allows many substances to cross)
- 2.Cytochrome P-450 isoenzymes are located in the placenta, and some may be inducible
These enzymes may metabolize agents and decrease fetal exposure
Placenta may also bind substances to minimize fetal exposure to and accumulation of substances