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Systemic Treatment of HER2-Negative Metastatic Breast Cancer

  • Soley Bayraktar
  • Adnan Aydiner
Chapter

Abstract

Chemotherapy regimens, either single-agent or combination, should be considered for patients with triple-negative metastatic or recurrent breast cancer or patients with hormone receptor-positive tumors and who are at high risk for a visceral crisis. No convincing data support the superiority of combination chemotherapy over single-agent chemotherapy. Although combination regimens may increase objective response rates, they also result in increased toxicity without any overall survival advantage. Patients who carry a BRCA mutation and have triple-negative or endocrine therapy-resistant metastatic breast cancer should be considered for platinum-based chemotherapy if they have received an anthracycline and a taxane in an adjuvant or metastatic setting. Poly (ADP)-ribose polymerase (PARP) inhibitors may be an option for patients with BRCA mutations. An understanding of the biology of breast cancer has led to important advances in the development of targeted therapies; however, metastatic breast cancer remains an incurable disease for most patients. As we continue to learn to use genomic medicine and harness the immune system to guide drug development, it is important to start combining drugs by using biologically informed translational science to optimize the patient outcomes.

Keywords

Metastatic HER2-negative BRCA PARP Triple-negative ER-positive PR-negative CDK4/6 inhibitors Everolimus Vinorelbine Ixabepilone Eribulin Paclitaxel Docetaxel Doxorubicin Epirubicin Pegylated liposomal doxorubicin Capecitabine Gemcitabine Platinum agents Parp inhibitors Bevacizumab 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Soley Bayraktar
    • 1
  • Adnan Aydiner
    • 2
  1. 1.Department of Medical Oncology, Memorial HospitalIstanbulTurkey
  2. 2.Internal Medicine, Medical Oncology, Istanbul Medical Faculty, Department of Medical Oncology, Institute of OncologyIstanbul UniversityIstanbulTurkey

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