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How Are These Devices Manufactured?

  • Giorgio Gianini Morbioli
  • Thiago Mazzu-Nascimento
  • Amanda M. Stockton
  • Emanuel CarrilhoEmail author
Chapter

Abstract

Paper-based devices are a portable and low-cost technology alternative among conventional analytical tools for point-of-care testing that have been growing in popularity due to their versatility and ease of use. Since their introduction in 2007, different methods to fabricate such devices have been proposed in literature, including photolithography, plotting, inkjet printing, wax printing, and stamping, among other methods, each with its unique advantages and drawbacks. Here, we present the most common current fabrication methods of microfluidic paper-based analytical devices (μPADs) in two and three dimensions, comparing their processes of fabrication, resolution of the features, and costs associated with their manufacture presenting insights towards the most adequate choice of fabrication method.

Keywords

Fabrication methods Photolithography Plotting Plasma treatment Wax printing Wax dipping Inkjet printing Inkjet etching Flexography printing Screen printing Laser treatment Stamping 

Notes

Acknowledgements

The authors would like to thank the funding agencies FAPESP (Grant No. 2011/13997-8), CNPq (Grant No. 205453/2014-7) by the scholarships and the financial support to the Instituto Nacional de Ciência e Tecnologia de Bioanalítica—INCTBio (FAPESP Grant Nr. 2008/57805-2/CNPq Grant Nr. 573672/2008-3), the Georgia Institute of Technology (Georgia Tech), and the State of Georgia, USA. The authors declare having no competing financial interests.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Giorgio Gianini Morbioli
    • 1
  • Thiago Mazzu-Nascimento
    • 2
    • 3
  • Amanda M. Stockton
    • 1
  • Emanuel Carrilho
    • 2
    • 3
    Email author
  1. 1.School of Chemistry and BiochemistryGeorgia Institute of TechnologyAtlantaUSA
  2. 2.Instituto de Química de São CarlosUniversidade de São PauloSão CarlosBrazil
  3. 3.Instituto Nacional de Ciência e Tecnologia de BioanalíticaCampinasBrazil

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