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Pathology of Head and Neck Tumors

  • Diana Bell
  • Michelle D. Williams
  • Adel K. El-NaggarEmail author
Chapter
  • 573 Downloads

Abstract

The chapter on head and neck surface epithelial-derived lesions presents recent developments in the classification of premalignant and malignant entities at different anatomical sites. Emphasis on close clinician and pathologist interactions in intraoperative consultation for both diagnosis and margins is stressed. The chapter provides a practical and simplified approach to the assessment of premalignant and dysplastic lesions in both oral and laryngeal sites. Emphasis on the significance of grading and morphologic subtypes is highlighted. The chapter also introduces and addresses the issues associated with the development of oropharyngeal carcinoma as an etiologic and clinical subtype. The HPV high-risk association, the morphologic manifestations, and the diagnosis of this entity are concisely presented with emphasis on biomarker integration.

Keywords

Premalignancy Squamous carcinoma Squamous tumorigenesis Risk factors Viral etiology Squamous carcinoma phenotypes 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Diana Bell
    • 1
  • Michelle D. Williams
    • 1
  • Adel K. El-Naggar
    • 1
    Email author
  1. 1.Department of PathologyUniversity of Texas M.D. Anderson Cancer CenterHoustonUSA

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