Cross-Sectional Imaging Indexes for Crohn’s Disease
Objective assessment of disease activity and complications in Crohn’s disease (CD) is critical to ensure accurate diagnosis and assessment of therapeutic response in both clinical practice and research. For recent clinical trials, patient selection and trial endpoints have been based on clinical symptoms and mucosal inflammation of the terminal ileum and large bowel determined on ileocolonoscopy. However, cross-sectional imaging methods have definite advantages over ileocolonoscopy and are potentially superior for use in CD clinical practice and trials. The development and validation of objective indexes of activity based on cross-sectional imaging will improve patient selection and assessment of the efficacy of new treatments.
KeywordsCrohn’s disease Activity Magnetic resonance Magnetic resonance enterography Computed tomography enterography Perianal disease
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