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Functional Cross-Sectional Imaging Techniques in Crohn’s Disease

  • Shankar Kumar
  • Nikhil Rao
  • Stuart A. TaylorEmail author
Chapter

Abstract

Imaging Crohn’s disease poses significant challenges, particularly in precisely defining disease activity and monitoring the adequacy of therapeutic response. Observations based on the structure of the bowel and extra-enteric tissues are the mainstay of radiological interpretation. However, functional techniques which extract information beyond simple anatomy also show considerable promise and may contribute to individualised management of Crohn’s disease patients. In this chapter, we summarise the importance and challenges posed by cross-sectional imaging of the bowel, focusing on magnetic resonance enterography (MRE). We then consider MR techniques that provide functional evaluation of the bowel over and above structure, including diffusion-weighted imaging (DWI), dynamic contrast-enhanced (DCE) imaging and assessment of bowel motility. Finally, we summarise the emerging data on the potential utility of positron emission tomography-magnet resonance imaging (PET-MRI) and positron emission tomography-computed tomography (PET-CT).

Keywords

Crohn’s disease Inflammatory bowel disease Imaging Radiology Magnetic resonance enterography MRE Diffusion weighted imaging DWI Dynamic contrast-enhanced magnetic resonance imaging DCE-MRI CINE Motility Positron emission tomography PET-MRI 

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Centre for Medical ImagingUniversity College LondonLondonUK

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