The New Ways of Preventing and Treating Diabetes Mellitus

  • Peter FaschingEmail author
Part of the Practical Issues in Geriatrics book series (PIG)


Strategies in midlife to prevent development of diabetes mellitus, mostly T2D mellitus (T2D), and its negative late sequela for health are of imminent importance for the individual as well as for societies and health systems. Healthy lifestyle and body-weight control in midlife play a crucial role in avoiding or postponing manifestation of T2D since lifestyle interventions appear more sustainable concerning their preventive potential in comparison to different pharmaceutical approaches which—up to now—loose efficacy after stopping and wash out and bear the risk of side-effects. Therefore, for the time being, no drug is licensed for diabetes prevention. Nonetheless, novel medicamentous attempts for diabetes prevention and supporting healthy aging are under scientific investigation.

If T2D is diagnosed, adequate lifestyle modification and modern pharmaceutical strategies are required to safely control hyperglycemia in order to prevent severe acute and chronic complications, especially severe hypoglycemia and premature cardiovascular complications and death. Diabetes prevention has important implications for health policy.


Type 2 diabetes mellitus prevention Weight management Frailty Metformin Pharmaceutical therapy Cardiovascular disease 



Body mass index




Cardiovascular disease


Cardiovascular outcome trial


Diabetes Prevention Program [14]


Dipeptidyl-peptidase 4 inhibitors


Diabetes Prevention Program Outcome Study [15]


Diabetes Prevention Study [13]


Glucagon-like-peptide 1 receptor agonist


Glycosylated hemoglobin A1c


Hazard ratio


International Diabetes Federation


Sodium-glucose-transporter 2 inhibitors


Sugar-sweetened beverages


Diabetes mellitus type 1


Diabetes mellitus type 2


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.5th Internal Department with Endocrinology, Rheumatology and Acute GeriatricsWilhelminenspital of the City of ViennaViennaAustria

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