Uncertainty Assessment of a Hybrid Cell-Continuum Based Model for Wound Contraction

  • Fred VermolenEmail author
Conference paper
Part of the Lecture Notes in Computational Science and Engineering book series (LNCSE, volume 126)


We assess the uncertainty in a hybrid cell-based, continuum-based model for wound contraction. We explore the correlations between the final contraction of a wound and the stiffness of the tissue, forcing applied by fibroblasts, plastic forces, death rate of cells, differentiation rate of cells, amount of random walk, and the chemotactic strength. Furthermore, we compute the likelihood that serious contractions occur. Although the current model is very simple, the principles can be used to unravel the most important biological mechanisms behind wound contraction.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Delft Institute of Applied Mathematics, Delft University of TechnologyDelftThe Netherlands

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