Uncertainty Assessment of a Hybrid Cell-Continuum Based Model for Wound Contraction
We assess the uncertainty in a hybrid cell-based, continuum-based model for wound contraction. We explore the correlations between the final contraction of a wound and the stiffness of the tissue, forcing applied by fibroblasts, plastic forces, death rate of cells, differentiation rate of cells, amount of random walk, and the chemotactic strength. Furthermore, we compute the likelihood that serious contractions occur. Although the current model is very simple, the principles can be used to unravel the most important biological mechanisms behind wound contraction.
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