Medical Management of Peptic Ulcer Disease

  • Ashley H. VernonEmail author


Peptic ulcers remain a common pathology found in the USA. With the identification of Helicobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) as major contributing factors in the formation of peptic ulcers, targeted medical management has become much more effective in mitigating severe complications. The widespread use of H2 receptor antagonists (H2RAs), proton pump inhibitors (PPIs), and H. pylori eradicating regimens has significantly decreased the need for surgical intervention. Due in large part to these advancements, there has also been a significant decline in the number of hospitalizations for peptic ulcer disease (PUD) in the USA decreasing from 222,000 to 156,000 (29.9%) from 1993 to 2006.


Peptic ulcers Helicobacter pylori NSAID ulcers 


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© SAGES 2019

Authors and Affiliations

  1. 1.Department of SurgeryBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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