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Historical Perspective: Evolution of the Diagnosis and Management of Barrett’s Esophagus

  • Reginald C. W. BellEmail author
Chapter

Abstract

The history of Barrett’s esophagus provides insight into current understanding not only of esophageal cancer but also of the anatomy and physiology of hiatal hernia and GERD. A current definition of Barrett’s esophagus is “the condition in which metaplastic columnar epithelium replaces the stratified squamous epithelium that normally lines the distal esophagus and predisposes to cancer development.” Although straightforward, the definition of and ability to precisely identify the esophagogastric junction and agreement on what constitutes metaplastic epithelium that predispose to cancer development remain problematic. Barrett’s esophagus is characterized by a metaplastic epithelium in the distal esophagus which may (or may not) be visualized as columnar epithelium during flexible endoscopy. To understand the history, definition, and current controversies surrounding Barrett’s esophagus requires an understanding of what defines the gastroesophageal junction and the various histologies present in this region.

Keywords

Barrett’s esophagus Esophageal cancer GERD 

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Copyright information

© SAGES 2019

Authors and Affiliations

  1. 1.Institute of Esophageal and Reflux SurgeryEnglewoodUSA

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