Systemic Chemotherapy in Brain Gliomas

  • George A. AlexiouEmail author
  • Athanasios P. Kyritsis


Gliomas constitute the most common and difficult to treat primary brain tumors, accounting for over 50% of all primary central nervous system tumors. The glioblastoma is by far the most frequently occurring and most malignant of the glial tumors, with a median patient survival of 15 months. Current treatment involves maximal surgical resection followed by radiotherapy with concomitant and adjuvant chemotherapy. However, over the last decade much has changed regarding the role of chemotherapy in gliomas. This is the result of several trials that reported survival benefit with a combination of agents and the incorporation of molecular genetic markers as predictors of response to chemotherapy. Herewith we discuss the chemotherapy regimens currently used for glioma treatment as well as the associated toxicities and try to provide an insight into future advancements.


Gliomas Brain Chemotherapy 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryUniversity Hospital of IoanninaIoanninaGreece
  2. 2.Department of Neurology and Neurosurgical InstituteUniversity Hospital of IoanninaIoanninaGreece

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